Method of intracellular sustained-release of drug and...

Details Method of intracellular sustained-release of drug and... Method of intracellular sustained-release of drug and...

2005-04-05

2005-04-05

Nguyen, Dave Trong (Department: 1632)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S450000, C435S458000, C435S320100

Reexamination Certificate

active

06875448

ABSTRACT:
A substance of interest is contained in nanospheres which are then encapsulated in fusogenic liposomes to prepare transport carriers that allow physiologically active substances, especially those having high molecular weight such as proteins and genes, to be introduced into cells efficiently and which permit the introduced active substance to be released in the cell at controlled rate. The fusogenic liposomes are prepared by conferring the fusogenic capability of Sendai virus to known liposomes.

REFERENCES:
patent: 5631237 (1997-05-01), Dzau et al.
patent: 5820879 (1998-10-01), Fernandez
patent: 20020064520 (2002-05-01), Rozenberg
patent: 09-110678 (1997-04-01), None
patent: 11-116499 (1999-04-01), None
patent: WO 9704747 (1997-02-01), None
H. Mizuguchi et al., “Application of Fusogenic Liposomes Containing Fragment A of Diphtheria Toxin to Cancer Therapy”,British Journal of Cancer,1996, pp. 472-476, vol. 73.

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