Method of inhibitor design and identification using a 3-D...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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C435S018000, C435S004000, C435S005000, C435S007210, C435S007220, C435S007320

Reexamination Certificate

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07747395

ABSTRACT:
The present invention provides the three-dimensional structure of human mitochondrialHomo sapienspeptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which have anti-bacterial, anti-viral, anti-parasitical, anti-inflammatory, and/or anti-cancer activity.

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