Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-08-30
2011-10-18
Lundgren, Jeffrey S (Department: 1629)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S315000, C514S453000
Reexamination Certificate
active
08039468
ABSTRACT:
The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention also discloses pharmaceutical compositions for use with the method, the composition containing in combination, an analgesic, anaesthetic, or a sedative and a positive allosteric AMPA receptor modulator in an amount sufficient to reduce or inhibit respiratory depression caused by the analgesic, anaesthetic, or sedative.
REFERENCES:
patent: 6730677 (2004-05-01), Rogers et al.
patent: 6943159 (2005-09-01), Gouliaev et al.
patent: 7026475 (2006-04-01), Ceci et al.
patent: 2002/0055508 (2002-05-01), Rogers et al.
patent: 2004/0082519 (2004-04-01), Hedner et al.
patent: 2006/0276532 (2006-12-01), Dominguez-Manzanares
patent: WO 94/02475 (1994-02-01), None
patent: WO 98/35950 (1998-08-01), None
Ge et al. (Journal of Physiology, vol. 509.1, pp. 255-266; 1998).
Sebel et al. (British Medicla Journal, vol. 289, pp. 1581-1582; 1984).
Looi-Lyons et al. (Journal of Clinical Anesthesia, vol. 8, pp. 151-156; 1996).
Arai, et al. “Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus,” 2004,mNeurosci., 123(4):1011-1024.
Bissonnette et al., “Non-NMDA Receptors Modulate Respiratory Drive in Fetal Sheep,” 1997, Journal of Physiology, 501.2, 415-423.
Black, “Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data.,” 2005, Psychopharmacol., 179, 154-163.
Denavit-Saubie et al., “Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat,” 1978,Brain Res., 155(1):55-67.
Feldman et al. “Looking for inspiration: new perspectives on respiratory rhythm,”2006,Nat. Rev. Neurosci., 7(3):232-24.
Funk, G.D., et al. “Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids,” (1993)J. Neurophysiol., 70(4):1497-1515.
Funk, G.D., et al. “Modulation of neural network activity in vitro by cyclothiazide, a drug that blocks desensitization of AMPA receptors” 1995,J. Neurosci., 15:4046-4056.
Goff, D.C., et al. “A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia,”J. Clin. Psychopharmacol., 21(5):484-487.
Greer J.J., et al. “Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat,” 1991,J. Physiol., 437:727-749.
Greer, J.J., et al. Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro,J. Neurophysiol., 67:996-999.
Horner et al., “Update in Sleep and Control of Ventilation,” 2007, Am. J. Respir. Crit. Care Med. 175, 426-431.
Johnson et al. “Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms,” 1996,J. Appl. Physiol., 80(6):2120-33.
Lauterborn et al. “Positive Modulation of AMPA Receptors Increases Neurotrophin,” 2000,J. Neurosci, 20:8-21.
Lynch “Glutamate-based therapeutic approaches: ampakines,” 2006,Curr. Op. Pharmacol,. 6:82-88.
Nagarajan et al. “Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546,” 2001,Neuropharmacol., 41:650-663.
Ren et al., “Ampakines Alleviate Respiratory Depression in Rats,” 2006, Am. J. Respir. Crit. Care Med., 174, 1384-1391.
Shook et al., “Differential roles of opioid receptors in respiration, respiratory disease, and opiate-induced respiratory depression.” 1990,Am. Rev. Respir. Dis., 142(4):895-909.
Thoby-Brisson et al. “Expression of Functional Tyrosine Kinase B Receptors by Rhythmically Active Respiratory Neurons in the Pre-Bötzinger Complex of Neonatal Mice,” 2003,J. Neurosci., 23:7685-7689.
Whitney et al., “AMPA Glutamate Receptors and Respiratory Control in the Developing Rat: Anatomic and Pharmacological Aspects,” 2000, Am. J. Physiol. Regulatory Integrative Comp. Physiol., 278: R520-528.
Blakely, III Nelson
Kilpatrick Townsend & Stockton LLP
Lundgren Jeffrey S
The Governors of the University of Alberta
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