Method of inhibition of HIV replication by leukemia...

Details Method of inhibition of HIV replication by leukemia... Method of inhibition of HIV replication by leukemia...

1999-11-19

2001-05-22

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S434000, C424S435000, C424S443000, C424S451000, C424S464000

Reexamination Certificate

active

06235304

ABSTRACT:

BACKGROUND OF THE INVENTION
The invention relates to a treatment for reducing and/or preventing HIV from infecting cells. More specifically, the invention involves preventing the HIV virus from replicating by using Leukemia Inhibitory Factors (“LIF”) to bind with its own specific receptors on T-lymphocytes or monocyte derived macrophages to prevent HIV replication.
SUMMARY OF THE INVENTION
Although the discovery of tropism specific HIV entry inhibitors began with Beta-chemokines, other factors with more global inhibitory function such as CAF (a CD8 derived antiviral factor)have been extensively studied but not unequivocally identified. The placenta remains an organ of intense study because vertical HIV transmission occurs in only 14-40% of untreated pregnancies despite exchange of blood between mother and fetus. A strong type 2 cytokine milieu (IL-4, IL-10) has been found in placentas from non-transmitting placentas that is significantly reduced in transmitting placentas. Associated with the type 2 cytokine response, it has not been found that non-transmitting placentas produce high levels of leukemia inhibitory factor (LIF). Thus, it has been determined that LIF is a potent inhibitor of HIV production with laboratory and primary isolates of HIV. Consequently, it has been found that LIF is involved in inhibition of both replication and vertical HIV transmission. As such, LIF may be used as a systemic treatment of infected individuals.


REFERENCES:
patent: 5837241 (1998-11-01), Ferrara

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