Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1989-09-01
1991-12-17
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514558, A01N 3700
Patent
active
050735713
ABSTRACT:
A method of inhibiting viruses by treatment with oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes is disclosed. These fatty acid analogs contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
REFERENCES:
patent: 4513005 (1985-04-01), Baker et al.
patent: 4709012 (1987-11-01), Adams et al.
patent: 4740588 (1988-04-01), Adams et al.
Towler and Glaser, Biochemistry 25, 878-84 (1986).
Towler and Glaser, Proc. Natl. Acad. Sci. U.S.A. 83, 2812-2816 (1986).
Towler et al., Ibid. 84, 2708-2712 (1987).
Towler et al., J. Biol. Chem. 262, 1030-1036 (1987).
Towler et al., Ann. Rev. Biochem., 57, 69-99, (1988).
The Merck Index, Tenth Ed., 1983, p. ONR-96.
Pascal and Ziering, J. Lipid Res. 27, 221-224 (1986).
Heuckeroth et al., J. Biol. Chem. 263(5), 2127-2133 (1988).
Aleynikov et al., Kolsk Branch of the USSR Academy of Sciences, May 3, 1961.
Below et al., Zhokh, vol. 1, No. 4, D. I. Mendeleev, Chem. Engineering Institute in Moscow, Apr. 18, 1964.
Heuckeroth et al., Proc. Nat'l. Acad. Sci. U.S.A. 85, 8795-8799 (1988).
Heuckeroth et al., Ibid. 86, 5262-5266 (1989).
Adams Steven P.
Gordon Jeffrey I.
Heuckeroth Robert O.
Meyer Scott J.
Travers Russell
Waddell Frederick E.
Washington University
Williams, Jr. James W.
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