Method of inhibiting viral reproduction using non-phospholipid,

Details Method of inhibiting viral reproduction using non-phospholipid, Method of inhibiting viral reproduction using non-phospholipid,

1994-06-24

1996-10-01

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

435236, 424 943, 424450, C12N 706, C12N 704, A61K 3854, A61K 9127

Patent

active

055610625

ABSTRACT:
A new method of inactivating enveloped viruses and preparations useful in accomplishing this inactivation are disclosed. The method is based on the discovery that paucilamellar lipid vesicles, preferably having non-phospholipids as their primary structural material, can fuse with enveloped virus and that the nucleic acid of the virus denatures shortly after the fusion. The method is useful for inactivating viruses such as orthomyxoviruses, paramyxoviruses, coronaviruses, and retroviruses.

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