Method of inhibiting tumor cell dissemination with a metalloprot

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 530350, A61K 3857

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057144656

ABSTRACT:
A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed. In particular, a method for inhibiting tumor cell dissemination in a mammal comprising administering an effective amount of such metalloproteinase inhibitors is described.

REFERENCES:
patent: 4710473 (1987-12-01), Morris
Stetler-Stevenson et al "Tissue Inhibitor of Metalloproteinase (TIMP-2)" J. Biol. Chem. 264(29):17374-17378 (Oct. 1989).
Goldberg et al "Human 72-kilodalton type IV collagenase forms a complex . . . " PNAS 86:8207-8211 (Nov. 1989).
Stetler-Stevenson et al "Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) . . . " J. Biol. Chem. 265(23): 13933-13938 (Aug. 1990).
Aggeler et al., J. Cell. Biol. 98,1662-1671 (1984).
Alvarez et al., J. National Cancer Inst., 1990) pp. 589-595.
Banda et al., Biochem. J. 193, 589-605 (1981).
Baron et al., Cell 28, 395-404 (1982).
Bauer et al., J. Exp. Med. 148, 1378-1387 (1978).
Birkedal-Hansen Methods Enzymol. 144,140-171 (1987).
Bitter et al., Methods in Enzymol. 153, 516-544 (1987).
Blockinger and Diegelman, Mol. Cell. Biol. 4, 2929-2931 (1984).
Boone et al., Proc. Natl. Acad. Sci. USA 87, 2800-2804 (1990).
Bradford Anal. Bioch. 72, 248-254 (1976).
Brown et al., American J. of Ophthalmology 72, 1139-1142 (1971).
Burnette, Anal. Biochem. 112, 195-203 (1981).
Carmichael et al., Proc. Natl. Acad. Sci. USA 83, 2407-2411 (1986).
Cawston et al. J.Biochem. 195, 159-165 (1981).
Cawston et al., J. Biochem. 211, 313-318 (1983).
Chen et al., Mol. Cell. Biol. 7, 2745-2752 (1987).
Chirgwin et al., Biochem. 18, 5294-5299 (1979).
De Clerck, Arch. Biochem. Biophys. 265, 28-37 (1988).
De Clerck et al. Cancer Research 46, 3580-3586 (1986).
De Clerck, Y.A. et al. (1989) J. Biol. Chem. 264, 17445-17453.
Tooze, ed., DNA Tumor Viruses, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY (1981), pp. 801-804.
Docherty et al. Nature 318, 65-69 (1985).
Andrews, Nature 295, (1982) pp. 185-186.
Dukes et al., Experimental Hematology 13, 59-66 (1985).
Ellman, G.L. Arch. Biochem. Biophys. 82, 70-771 (1984).
Evanson et al. J. Clin. Invest. 47, 2639-2651 (1968).
Fidler, Nature 242, 148-149 (1973).
Gasser et al., Proc. Natl. Acad. Sci. USA 79, 6522-6526 (1982).
Glorieux et al., Cancer 58, 2136-2139 (1986).
Graeve et al., Cancer 62, 2125-2127 (1988).
Grant et al., J. Biol. Chem. 262, 5886-5889 (1987).
Guarente et al., Proc. Natl. Acad. Sci. USA 79, 7410-7414 (1982).
Guarente et al., Cell 36, 503-511 (1984).
Herron et al., J. Biol. Chem. 261, 2814-2818 (1986).
Hewick et al., J. Biol. Chem. 256, 7990-7997 (1981).
Hibbs et al., J. Biol. Chem. 260, 2493-2500 (1985).
Hicks et al., Int. J. Cancer 33, 835-844 (1984).
Jiminez et al., Nature 287, 869-871 (1980).
Johnson-Wint Anal. Biochem., 104, 175-181 (1980).
Jones and De Clerck, Cancer Res. 40, 3220-3227 (1980).
Jones et al. Cancer Res. 41, 4613-4620 (1981).
Kohler and Milstein Eur. J. Immunol. 6, 511-519 (1976).
Kaiser et al. Science 223, 249-255 (1984).
Kaufman and Sharp, J. Mol. Biol. 159, 601-621 (1982).
Laemmli Nature 227, 680-685 (1970).
Lathe, J. Mol. Biol. 183, 1-12 (1985).
Lerner et al., Cell 23, 309-310 (1981).
Lerner et al., Proc. Natl. Acad. Sci. USA, 78 3403-3407 (1981).
Lerner, Scientific American 248, 66-74 (1983).
Lin et al. Gene 44, 201-209 (1986).
Liotta et al., Biochem. Biophys. Res. Commun. 98, 124-198 (1981).
Liotta et al., Nature 284, 67-68 (1980).
Liotta et al., Proc. Natl. Acad. Sci. USA 76 2268-2272 (1979).
Lu et al. J. Chromatog. 368, 215-231 (1986).
McCartney et al. Eur. J. Biochem. 130, 79-83 (1983).
Morrissey, Anal. Biochem. 117, 307-310 (1981).
Gelpi et al. Biochem. J. 283, 289-221 (1982).
Murphy et al. J. Biochem. 195, 167-170 (1981).
Murphy et al., Biochem. J. 192, 517-525 (1980).
Murray et al. J. Biol. Chem. 261, 4154-4159 (1986).
Okayama and Berg, Mol. Cell. Biol. 3, 280-289 (1983).
Palmiter et al., Science 222, 809-814 (1983).
Pisko et al. J. Immunol. 136, 2141-2150 (1986).
Pozzatti et al. Science 232, 223 (1986).
Khokha et al., Science 243, 947-950 (1986).
Ross et al., Nature 294, 654-656 (1981).
Salo et al., J. Biol. Chem. 258, 3058-3063 (1983).
Sambrook et al. (1989) Molecular Cloning. A Laboratory Manual, pp. xi-xxxviii.
Sanger et al., PNAS USA 74, 5463-5467 (1977).
Schultz et al., Cancer Research 48, 5539-5545 (1988).
Schultz et al., Proteins: Structure, Function and Genetics 2,290-297 (1987).
Seiki et al. PNAS USA 80, 3618-3622 (1983).
Slansky et al., Annals of Ophthalmology 2, 488-491 (1970).
Stricklin et al., J. Biol. Chem. 258, 12252-12258 (1983).
Takebe et al., Mol-Cell. Biol. 8, 466-472 (1988).
Thorgeirsson et al., J. Natl. Canc. Inst. 69, 1049-1054 (1982).
Tomayko and Reynolds, Cancer Chemother. Pharmacol. 24, 148 (1990).
Tramontano et al. (Nucleic Acid Res. 12, 5049-5059 (1984).
Tsai et al. J. Indust. Microbiol. 2, 181-187 (1987).
Tschumper et al. Gene 10, 157-166 (1980).
Tschumper et al., Gene 23, 221-232 (1983).
Tsu et al., "Solid Phase Radioimmunoassays", pp. 373-397 in Selected Methods in Cellular Immunology,(1980).
Uitto, pp. 211-223 in Proteinases in Inflammation and Tumor Invasion, H. Tschesche, ed., Walter de Gruyter & Co., Berlin, N.Y. (1988).
Walter et al., PNAS USA 78, 4882-4886 (1981).
Walter et al., PNAS USA 77, 5197-5200 (1980).
Weiland et al., Blut 44, 173-175 (1982).
Werb et al. J. Exp. Med. 142, 346-360 (1975).
Williamson et al., Biochem. J. 268, 267-274 (1990).
Nigg et al., PNAS USA, 79 5322-5326 (1982).
Woolley et al. Arthritis and Rheumatism 20, 1231-1239 (1977).
Zoller and Smith Methods Enzymol. 154, 329-240 (1987).
Zsebo et al., J. Biol. Chem. 261, 5858-5865 (1986).

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