Method of inhibiting thrombus formation by the 7E3 monoclonal an

Details Method of inhibiting thrombus formation by the 7E3 monoclonal an Method of inhibiting thrombus formation by the 7E3 monoclonal an

1991-09-27

1995-02-07

Lacey, David L.

Drug, bio-affecting and body treating compositions

Involving sex selection or contraception

5303887, A61K 39395, C07K15128

Patent

active

053874137

ABSTRACT:
The monoclonal antibody designate 7E3 blocks the interaction of fibrinogen with platelets, prevents thrombus formation, reacts with both human and dog platelets and fails to react with thrombasthenic human platelets or human platelets whose GPIIb/IIIa complex is dissociated with EDTA. A fragment of the 7E3 antibody can prevent occlusion by thrombus in the circulatory system.

REFERENCES:
patent: 5275812 (1994-01-01), Gold et al.
Gold et al. J. Clin. Invest. 86:651-659 (1990).
Yasuda et al. J. Clin. Invest. 81:1284-1291 (1988).
Harker Am J Cardiol 60:20B-28B (1987).
Coller et al. J Clin Invest. 72:325-338 (1983).
Hanson et al. Annals NY Acad Sciences 416:642-651 (1983).

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