Method of inhibiting the transport of L-glutamate to treat CNS d

Details Method of inhibiting the transport of L-glutamate to treat CNS d Method of inhibiting the transport of L-glutamate to treat CNS d

1993-08-09

1999-08-24

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 91, 514424, 514425, A61K 31575, A61K 3140

Patent

active

059425377

ABSTRACT:
A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2## or CONHR.sup.3 in any combination and and wherein R.sup.2 =OR.sup.3, NR.sup.3.sub.2, alkyl, or substituted alkyl and R.sup.3 =alkyl or substituted alkyl.

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Bridges et al., J. Neurochem. 48:1709-1715 (1987).
Ferkany and Coyle, J. Neurosci. Res. 16:491-503 (1986).
Davies et al., Neuropharmacology 24:177-180 (1985).
King and Wheal, Eur. J. Pharmacol. 102:129-134 (1984).
Jais et al., Comp. Biochem, Physiol. 77C:385-389 (1984).

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