Method of inhibiting the proliferation and causing the different

Details Method of inhibiting the proliferation and causing the different Method of inhibiting the proliferation and causing the different

1995-06-06

1997-07-01

Rories, Charles C.P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 911, 4351721, 4351723, 435375, 536 243, 536 2431, 536 2432, 536 2433, 536 245, 536 251, 514 44, C12N 510, C07H 2100, A61K 3170, C12Q 168

Patent

active

056437889

ABSTRACT:
A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons -29 to -24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.

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