Method of inhibiting the onset of septicemia and endotoxemia

Details Method of inhibiting the onset of septicemia and endotoxemia Method of inhibiting the onset of septicemia and endotoxemia

1986-11-25

1989-07-04

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 514 23, 514 54, 514917, 514921, A61K 3720

Patent

active

048448940

ABSTRACT:
The present invention is directed to a method of inhibiting to onset of septicemia and endotoxemia. The methods comprise administering to a warm-blooded animal an effective amount of a pharmaceutical composition comprising Monophosphoryl lipid A in combination with a pharmaceutically acceptable carrier.

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patent: 4436728 (1984-03-01), Ribi et al.
patent: 4663306 (1987-05-01), Cantrell
Ziegler et al., Jama vol. 307(20) 1982, pg. 1225.
Hinshaw et al., CA vol. 87, #9 56n; 1977.
Balogh et al. CA vol. 97, 1982 #86685q.
Balogh et al. CA vol. 101, 1984 #103796X.
Tomai et al., CA vol. 107, 1987 #17442w.
Masihi et al., CA vol. 105, 1986, #95672u.
Ribi et al., CA vol. 105, 1986 #53908v.
Chase et al., Inf. and Immunity 53(3) 1986, pp. 711-712.
"Infection and Immunity", Aug. 1984, p. 350-355 (esp. 352).

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