Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-03-07
1989-08-22
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142355, 5142388, A61K 31535
Patent
active
048596680
ABSTRACT:
A method of inhibiting the growth of melanin-pigmented cells in a subject having need of such treatment is provided in which the subject is administered a cyclic amine which is selectively toxic to melanin-pigmented cells. Such cyclic amines include morpholine; piperazine; piperidine; N-methylpiperidine; N-methylpiperazine; 1,4 dimethylpiperazine; 2,5 dimethylpiperazine; piperidinopyridine and piperidino 1,2 propanediol for a time period and in a concentration sufficient to inhibit the growth rate of the cells without substantially affecting nonpigmented cells. Treatment of the subject by also administering a tyrosinase stimulator such as theophylline markedly increases the selective toxicity of the cyclic amine to the melanin-pigmented cells.
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Barthalmus George T.
Noga Edward J.
Friedman Stanley J.
North Carolina State University
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