Method of inhibiting the growth of bFGF-dependent neoplastic cel

Details Method of inhibiting the growth of bFGF-dependent neoplastic cel Method of inhibiting the growth of bFGF-dependent neoplastic cel

1994-12-21

1996-12-10

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

530351, 530399, 435 691, 4352402, 536 221, 935 33, 935 34, C07K 1450, C12N 1500, C12N 500, C07H 2104

Patent

active

055831168

ABSTRACT:
A method of inhibiting the growth of bFGF-dependent neoplastic cells is disclosed. The method includes the steps of accessing a selected colony of such cells and adding a bFGF-specific antisense primer to such colony. By performing the adding step, there is downregulating of the expression of colony-intracellular bound bFGF, and by performing the downregulating step, there is inhibiting of bFGF-promoted growth of cells in the colony.

REFERENCES:
Gene Expession of Fibroblast Growth Factors . . . , Takahashi, Jun A. et al., Proc. Natl. Acad. Sci. USA, vol. 87, pp. 5710-5714, Aug., 1990.
Supression of Solid Tumor Growth by Immunoneutrailizing . . . , Hori, Akira et al., Biology Research Laboratories, Nov. 15, 1991, pp. 6180-6184.
Correlation of Basic Fibroblast Growth Factor Expression Levels . . . , Takahashi, Jun. A., J. Neurosurg., vol. 76, May, 1992, pp. 792-798.
Localization of Basic Fibroblast Growth Factor, a Mitogen . . . , Paulus, w. et al. Acta Neuropathol, 79:418-423, 1990.
Immunohistochemical Localization of Basic Fibroblast Growth FActor in Astrocytomas, Zagzag, David et al., Cancer Research 50, 7393-7398, Nov. 15, 1990.
Acidic and Basic Fibroblast Growth Factors are Present in Glioblastoma Multiforme Stefanik, David F. et al., Cancer Research 51, 5760-5765, Oct. 15, 1991.
Expression of Angiogenic Growth Factor Genes in Primary Human Astrocytomas . . . , Maxwell, Marius et al., Cancer Research 51, 1345-1351, Feb. 15, 1991.
Localization of Acidic and Basic Fibroblast Growth Factor mRNA . . . , Akutsu, Yasuhiko et al., Jpn. J. Cancer Res. 82, 1022-1027, Sep. 1991.
Increased Expression of Genes from Growth Factor Signalling . . . , Saxena Abha et al., Oncogene 7, 243-247, 1992.
Gene Expression of Fibroblast Growth Factor Receptors in the Tissue . . . , Takahashi, Jun A., et al., Biochemical and Biophysical Research Communications, vol. 177, No. 1, 1991, pp. 1-7.
Lee et al 1989 Science 245:57-60.
Abraham et al 1986 EMBO J. 5(10):2523-2528.
Sommer et al 1989 BBRC 160(3):1267-1274.
Becker et al 1989. EMBO J. 8(12):3685-3691.
Takahashi et al 1991. FEBS 288:65-71.

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