Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-18
2008-12-30
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252110, C514S252140, C514S256000, C514S274000, C544S122000, C544S295000, C544S296000, C544S310000, C544S315000, C544S333000
Reexamination Certificate
active
07470686
ABSTRACT:
The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation.X is O, S or NR0, with R0being H or an unsubstantiated or substituted C1-C6alkyl;G is an unsubstantiated or substituted pyrimidinyl group.
REFERENCES:
patent: 2918369 (1959-12-01), Doorenbos et al.
patent: 4064136 (1977-12-01), Loew et al.
patent: 1 963 542 (1971-06-01), None
patent: 26 17 345 (1979-03-01), None
patent: 0 364 765 (1990-04-01), None
patent: 11-80155 (1999-03-01), None
patent: WO 98/49188 (1998-11-01), None
patent: WO 99/21859 (1999-05-01), None
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Sah et al., Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by TRAIL by Activating c-Jun N-terminal Kinase, The Journal of Biological Chemistry, vol. 278, No. 23, pp. 20593-20602, Jun. 2003.
Augustin et al,J Prakt Chem GE324(1):3-11 (1982): Beilstein Registry Nos. 5589714, 5589715, 5589716, 5589718, 5589719, 5589720, 5589722, 5589723, and 5601864, Beilstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Biehl et al, “LDA (lithium diisopropylamide) mediated reactions of 1-naphthalynes with lithiated acetonitriles and 1,4-dipolar nucleophilic anions”,Synthesis9:885-889 (1993).
Chabaka et al, “Facile Synthesis of 2-Furyl-, 2-Pyrrolyl-, 2-Imidasolyl- and Pyrrolo-Azoles from 2-Substituted methylazoles”,Polish J Chem68:1317-1325 (1994).
Deshmukh et al, “An Investigation of the Influence of Haloarenes and Hetarylacetonitriles on the Completition between Possible Aryne Arylation and Tandem Addition-Rearrangement Pathways”,Heterocycles34(6):1239-1249 (1992) (Database Chemical Abstracts ′Online!—CAS, AC117-233221).
Fanghaenel et al,J Prakt Chem GE4:590-606 (1988): Beilstein Registry Nos. 6226072, 6220826, 6220828, 6235458 and 6131469, Beinstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Hassan et al, “Reactions of Benzimidazolyl-Acetonitrile and Methanethiol with Eelectron Deficient Compounds”,Chemical Abstracts126(6):583 (Abstract No. 74791a) (1997),Chemical Abstracts126(1):1990F (Formula Index), andHeterocycl Commun2(5):441-446 (1996), and.
Huang et al, “Synthesis, Reactions, and Tautomerism of Ketene N,S-Acetals with Benzothiazoline Ring”,Chemische Berichte123(3):541-547 (1990).
Hunger et al, “Benzimidazol-Derivative und verwandte Heterocyclean VI) Synthese von Phenyl-1-aminoalkyl-benzimidazolyl-(2)-essigsäure-estern und -amiden”,Helvetica Chimica Acta43(6):1727-1733 (1960).
Kiprianov et al,J Org Chem USSR1:757-762 (1965): Beilstein Registry Nos. 5395626, 5395012, 539500 and 5392953, Beilstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Kozynchenko et al,Khim Geterotsikl Soedin RU8:1119-1123 (1988): Beilstein Registry Nos. 5115381, 5130108, 516287 and 5169755, Beilstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Kumagae et al, “Human c-Jun N-terminal kinase expression and activation in the nervous system”,Brain Res Mol Brain Res67(1):10-17 (1999).
Maroney et al, “Motoneuron apoptosis in blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway”,J Neurosci18(1):104-111 (1998).
Sabapathy et al, “JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development”,Curr Biol9(3):116-125 (1999).
Satzinger G,Justus Liebigs Ann Chem, pp. 473-511 (1978): Beilstein Registry No. 1128326, Beilstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Volovenko et al, “Synthesis and biological activiy of α-substituted 2-pyridylacetonitriles”,Chemical Abstracts117(23):850 (Abstract No. 233799a) (1992).
Xie et al, “Crystal structure of JNK3: a.kinase implicated in neuronal apoptosis”,Structure6(8):983-991 (1998).
Yamanaka et al,Heterocycles31(6):1115-1127 (1990): Beilstein Registry Nos. 3616487 and 3614951, Beilstein Institut fuer Literature der Organischen Chemie (Database Crossfire ′Online!).
Yang et al, “Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene”,Nature389(6653):865-870 (1997).
Yang et al, “Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2”,Immunity9(4):575-585 (1998).
Zakhs et al,J Org Chem USSR15:200 (1979): Beilstein Registry Nos. 855092, 861654 and 874268, Beilstein Institut fuer Literatur der Organischen Chemie (Database Crossfire ′Online!).
Database Accession No. 2001:22334—Chemical Abstracts Service and “Interbioscreen Compound Library” (Aug. 1, 2000) (Database Chemcats ′Online!).
Database Accession No. 2001:391108—Chemical Abstracts Service and “Enamine Product Listing” (Sep. 6, 2000) (Database Chemcats ′Online!).
Database Accession No. 2001:95296—Chemical Abstracts Service and “Enamine Product Listing” (Aug. 1, 2000) (Database Chemcats ′Online!).
Sah et al., Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligang (TRAIL) by activating c-Jun N-terminal kinase,The Journal of Biological Chemistry, 278(23)20593-26002 (Jun. 2003).
Johnson et al., Mitogen activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinase, 298:1911-1912 (Dec. 6, 2002).
Camps Monstserrat
Church Dennis
Gaillard Pascale
Gotteland Jean-Pierre
Halazy Serge
Browdy and Neimark PLLC
Laboratoires Serono SA
Rao Deepak
LandOfFree
Method of inhibiting the expression and/or the activity of JNK does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inhibiting the expression and/or the activity of JNK, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inhibiting the expression and/or the activity of JNK will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4023205