Method of inhibiting the emigration of cells from the...

Details Method of inhibiting the emigration of cells from the... Method of inhibiting the emigration of cells from the...

2008-02-20

2010-06-22

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S328000, C514S825000, C514S826000, C514S886000

Reexamination Certificate

active

07741292

ABSTRACT:
A method of inhibiting the emigration of cells from the intravascular compartment into tissues (or through any membrane limiting any body compartment from another) by confronting the cells with an agonist specific for receptors involved with migration of said cells via a receptor thereby making the cell unresponsive to further activation.

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Mosier, 1999, Journal of Virology, 73, 3544-3550.
Detheux, M., et al., “Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties,” The Journal of Experimental Medicine, vol. 192, No. 10, Nov. 20, 2000, pp. 1501-1508, [XP002241991].
Muench, J., et al., “Hemofiltrate CC chemokine 1(9-74) causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages,” Antimicrobial Agents and Chemotherapy, vol. 46, No. 4, Apr. 2002, pp. 982-990, [XP002241992].
Teran, L. M., “CCL Chemokines and asthma,” Immunology Today, vol. 21, No. 5, May 2000, pp. 235-242, [XP004198513].
Mosier et al., “High Potent RANTES Analogues either Prevent CCR5-Using Human Immunodeficiency Virus Type 1 Infection In Vivo or Rapidly Select for CXCR4-Using Variants”Journal of Virology, 73(5):3544-3550 (May 1999).

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