Method of inhibiting the degradation of hepatocyte growth factor

Details Method of inhibiting the degradation of hepatocyte growth factor Method of inhibiting the degradation of hepatocyte growth factor

1996-05-07

1998-04-07

Sayala, Chihaya D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 54, 514 56, 514 59, 514 62, 530399, A01N 3718

Patent

active

057365067

ABSTRACT:
A method for inhibiting the degradation of a hepatocyte-growth factor (HGF) which comprises combining at least one polysaccharide or a derivative thereof with a hepatocyte-growth factor (HGF) is disclosed. The polysaccharides include heparin, hyaluronic acid, dextran, dextran sulfate, heparan sulfate, dermatan sulfate, keratan sulfate, chondroitin, and chondroitin sulfate.

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patent: 5545722 (1996-08-01), Naka
Zarnegar et al., "Purification and Biological Characterization of Human Hepatopoietin A, A Polypeptide Growth Factor for Hepatocytes", Cancer Research 49: 3314-3320 (1989).
Zarnegar et al., "Identification and Partial Characterization of Receptor Binding Sites for HGF on Rat Hepatocytes", Biochem. Research Communications 173(3): 1179-1185 (1990).
Ruoslahtl et al., "Proteoglycans as Modulators of Growth Factor Activities", Cell 64: 867-869 (1991).
Taiho Pharm KK, English Language Abstract of Japanese Provisional Patent Publication No. 2000213/1990.
Arakaki et al., "Identification and Partial Characterization of Two Classes of Receptors for Human Hepatocyte Growth Factor On Adult Rat Hepatocytes in Primary Culture," J. Biol. Chem. 267(10):7101-7107 (1992).
Komada et al., "Characterization of hepatocyte-growth-factor receptors on Meth A cells," Eur. J. Biochem. 204: 857-864 (1992).
Roghani et al., "Basic Fibroblast Growth Factor Is Internalized through Both Receptor-mediated and Heparan Sulfate-mediated Mechanisms," J. Biol. Chem. 267(31): 22156-22162 (1992).
Mizuno K., et al., "Cell Structure and Function", vol. 17(6):469, (1992), Abstract #1A-1300.

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