Method of inhibiting the activity of .alpha.-amylase

Details Method of inhibiting the activity of .alpha.-amylase Method of inhibiting the activity of .alpha.-amylase

1992-10-19

1994-06-07

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3135

Patent

active

053189868

ABSTRACT:
The effective ingredient in the inventive inhibitive agent against activity of a .alpha.-amylase is tea, e.g., black tea, or a tea polyphenol as a constituent of tea including epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, (+)catechin and the isomer thereof, free theaflavin, theaflavin monogallates A and B and theaflavin digallate.

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patent: 4840966 (1989-06-01), Hara et al.
E. Truscheit et al, "Chemistry and Biochemistry of Microbial .alpha.-Glucosidase Inhibitors", 1981, pp. 744-761, Angew. Chem. Int. Ed. Engl. 20.
Choi-Lan Ha et al, "In vitro inhibition of trypsin and .alpha.-amylase activities by tea", vol. 27, No. 3, Sep. 1989, pp. 406-417-Journal of the Chinese Agriculture Chemical Society.
S. Kashket et al, "Inhibition of Salivary amylase by water-soluble extracts of tea", vol. 33, No. 11, 1988, pp. 845-846-Archives of Oral Biology.
Y. Hara et al, "the inhibition of .alpha.-amylase by tea polyphenols", vol. 54, No. 8, aug., 1990, Japan, pp. 1939-1945-Agricultural and Biological Chemistry.
Chakraravarthy et al. 95CA:215159f 1981.
Ha et al. 112 CA:177157p 1989.
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