Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-12-17
1995-10-31
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514559, 514560, 514561, 514562, 514563, 514529, 514922, A61K 4900
Patent
active
054627265
ABSTRACT:
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives thereof, such as Cremophor, or (b) caused by a drug, such as cyclosporine A, dissolved or suspended in solvents such as ricinoleic acid or castor oil or derivative thereof, employing a thromboxane A.sub.2 receptor antagonist. Solvent compositions containing ricinoleic acid or castor oil or derivatives thereof and a thromboxane A.sub.2 receptor antagonist, and pharmaceutical compositions including a drug, solvent containing ricinoleic acid or castor oil or derivative thereof, and a thromboxane A.sub.2 receptor antagonist are also provided.
REFERENCES:
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Racusen et al., CA 106:149103, "Early renal pathophysiology in an acute model of cyclosporine nephrotoxicity in rats", Renal Failure, vol. 10(1), pp. 29-37, 1987. Abstracts only.
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Martindale, The Extra Pharmacopoeia, 30th Edition, 1993, London, The Pharmaceutical Press.
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Transplantation, Nov. 1991, 52(5), pp. 873-878, ISSN 0041-1337.
Bristol--Myers Squibb Company
Henley III Raymond
MacMillan Keith
Rodney Burton
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