Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-03
2006-10-03
Krass, Fredrick (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S229800, C514S202000, C514S205000, C514S208000, C514S302000, C514S362000, C514S363000, C514S365000, C514S372000, C514S374000, C514S381000, C514S383000, C514S364000, C514S396000, C514S403000, C514S414000, C514S417000, C514S607000, C514S621000, C514S625000, C435S021000
Reexamination Certificate
active
07115624
ABSTRACT:
The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.
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Iversen et al., The Journal of Biological Chemistry, 275(14): 10300-10307 (2000).
Andersen Henrik Sune
Axe Frank Urban
Ge Yu
Hansen Thomas Kruse
Holsworth Daniel Dale
Bork Richard W.
Green Reza
Krass Fredrick
Lewis Amy
Novo Nordisk A S
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