Method of inhibiting picornavirus disease

Details Method of inhibiting picornavirus disease Method of inhibiting picornavirus disease

1991-01-31

1993-07-20

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

4351723, 4353171, 4353201, 935 56, 935 57, 935 65, A61K 3912, C12N 1500

Patent

active

052291111

ABSTRACT:
A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.

REFERENCES:
patent: 4743554 (1988-05-01), Boothroyd et al.
Osorio, J. et al., "Attenuation of Mengovirus Pathogenicity Through Recombinant Engineering of the Poly(C) Tract," In American Society for Virology 8th Annual Meeting, Jul. 9-13, 1989 (Abstract).
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Duke, G. M. and A. C. Palmenberg, "Cloning and Synthesis of Infectious Cardiovirus RNAs Containing Short, Discrete Poly(C) Tracts," J. Virology 63[4] 1822-1826 (1989).
Duke, G. M. et al., "Attenuation of Mengovirus Through Genetic Engineering of the 5' Noncoding Poly(C) Tract," Nature 343[6257] 474-476 (Feb. 1, 1990).
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