Method of inhibiting pathogenicity of infectious agents

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S007100, C435S032000, C436S501000

Reexamination Certificate

active

07001718

ABSTRACT:
The present invention relates to methods of detecting or identifying inhibitors of a Z-DNA binding ligand to Z-DNA, methods of inhibiting the pathogenicity of an infectious agent, antiviral therapies, and compounds that inhibit complex formation between a Z-DNA binding ligand and Z-DNA.

REFERENCES:
patent: 5726050 (1998-03-01), Rich et al.
patent: WO 97/00949 (1997-01-01), None
patent: WO 00/73487 (2000-12-01), None
Herbert et al (Genetica 106:37-47, 1999, abstract only cited).
Inoue et al, BBRC 266:147-151, 1999.
Blaho et al, Journal of Biological Chemistry 262:6062-6068, 1987.
Kim, Y.G. et al., “A Role for Z-DNA Binding in Vaccinia Virus Pathogenesis,”Proc. Natl. Acad. Sci. USA, 100(12):6974-6979 (2003).
Rich, A. et al., “Z-DNA: The Long Road to Biological Function,” Nature Reviews, 4(7):566-572 (2003).
Oh, D.-B., et al., “Z-DNA-Binding Proteins Can Act as Potent Effectors of Gene ExpressionIn Vivo,” Proceedings of the National Academy of Sciences U.S.A., 99(26):16666-16671 (2002).
Kim, Y.-G., et al., “A Role for Z-DNA Binding in Vaccinia Virus Pathogenesis,”Proceedings of the National Academy of Sciences U.S.A., 100(12):6974-6979 (2003).
Behe, M. and Felsenfeld, G., “Effects of Methylation on a Synthetic Polynucleotide: The B-Z Transition in Poly(dG-m5dC) • Poly(dG-m5dC),”Proceedings of the National Academy of Sciences U.S.A., 78:1619-1623 (1981).
Berger, I., et al., “Spectroscopic Characterization of a DNA-Binding Domain, Zα, from the Editing Enzyme, dsRNA Adenosine Deaminase: Evidence for Left-Handed Z-DNA in the Zα-DNA Complex,”Biochemistry, 37:13313-13321 (1998).
Bloom, D.C., et al., “Identification and Characterization of Two Nonessential Regions of the Rabbitpox Virus Genome Involved in Virulence,”Journal of Virology, 65:1530-1542 (1991).
Brandt, T.A. and Jacobs, B.L., “Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model,”Journal of Virology, 75:850-856 (2001).
Brigido, M.M. and Stollar, B.D., “Two Induced Anti-Z-DNA Monoclonal Antibodies Use VH Gene Segments Related to Those of Anti-DNA Autoantibodies,”The Journal of Immunology, 146:2005-2009 (1991).
Brown, B.A., et al., “The Zα Domain of the Editing Enzyme dsRNA Adenosine Deaminase Binds Left-Handed Z-RNA as Well as Z-DNA,”Proceedings of the National Academy of Sciences U.S.A., 97:13532-13536 (2000).
Enserink, M. And Stone, R., “Dead Virus Walking,”Science, 295:2001-2003 and 2005 (Mar., 2002).
Fu, Y., et al., “Cloning of DLM-1, A Novel Gene that is Up-Regulated in Activated Macrophages, Using RNA Differential Display,”Gene, 240:157-163 (1999).
Herbert, A. and Rich, A., “The Biology of Left-Handed Z-DNA,”The Journal of Biological Chemistry, 271:11595-11598 (1996).
Herbert, A.G. and Rich, A., “A Method to Identify and Characterize Z-DNA Binding Proteins Using a Linear Oligodeoxynucleotide,”Nucleic Acids Research, 21:2669-2672 (1993).
Herbert, A., et al., “A Z-DNA Binding Domain Present in the Human Editing Enzyme, Double-Stranded RNA Adenosine Deaminase,”Proceedings of the National Academy of Sciences U.S.A., 94:8421-8426 (1997).
Herbert, A., et al., “The Zα Domain from Human ADARI Binds to the Z-DNA Conformer of Many Different Sequences,”Nucleic Acids Research, 26:3486-3493 (1998).
Jiang, H., et al., “Potassium Permanganate as anIn SituProbe for B-Z and Z-Z Junctions,”Nucleic Acids Research, 19:6943-6948 (1991).
Kibler, K.V., et al., “Double-Stranded RNA Is a Trigger for Apoptosis in Vaccinia Virus-Infected Cells,”Journal of Virology, 71:1992-2003 (1997).
Kim, J-M., et al., “Analysis of Left-Handed Z-DNA Formation in Short d(CG)ηSequences inEscherichia coliandHalobacterium halobiumPlasmids,”The Journal of Biological Chemistry, 271:9340-9346 (1996).
Kim, Y-G., et al., “Construction of a Z-DNA-Specific Restriction Endonuclease,”Proceedings of the National Academy of Sciences USA, 94:12875-12879 (1997).
Kim, Y-G., et al., “The Interaction Between Z-DNA and the Zab Domain of Double-Stranded RNA Adenosine Deaminase Characterized Using Fusion Nucleases,”The Journal of Biological Chemistry, 274:19081-19086 (1999).
Kim, Y-G., et al., “The Zab Domain of the Human RNA Editing Enzyme ADAR1 Recognizes Z-DNA When Surrounded by B-DNA,”The Journal of Biological Chemistry, 275:26828-26833 (2000).
Liu, J., et al., “Identifying DNA-Binding Sites and Analyzing DNA-Binding Domains Using a Yeast Selection System,”Methods: A Companion to Methods in Enzymology, 5:125-137 (1993).
Qu, X, et al., “Allosteric, Chiral-Selective Drug Binding to DNA,”Proceedings of the National Academy of Sciences U.S.A., 97:12032-12037 (Oct., 2000).
Rich, A., “A Therapy for Smallpox,”CRISP—Computer Retrieval of Informational on Scientific Projects, National Institutes of Health, http://commons.cit.nih.gov (2002) Abstract.
Schade, M., et al., “Structure-Function Analysis of the Z-DNA-Binding Domain Zα of dsRNA Adenosine Deaminase Type I Reveals Similarity to the (α+β) Family of Helix-Turn-Helix Proteins,”The EMBO Journal, 18:470-479 (1999).
Schade, M., et al., “The Solution Structure of the Zα Domain of the Human RNA Editing Enzyme ADAR1 Reveals a Prepositioned Binding Surface for Z-DNA,”Proceedings of the National Academy of Sciences U.S.A., 96:12465-12470 (1999).
Schwartz, T., et al., “Crystal Structure of the Zα Domain of the Human Editing Enzyme ADAR1 Bound to Left-Handed Z-DNA,”Science, 284:1841-1845 (1999).
Schwartz, T., et al., “Proteolytic Dissection of Zab, the Z-DNA-Binding Domain of Human ADAR1,”The Journal of Biological Chemistry, 274:2899-2906 (1999).
Schwartz, T., et al., “Structure of the DLM-1-Z-DNA Complex Reveals a Conserved Family of Z-DNA-Binding Proteins,”Nature Structural Biology, 8:761-765 (2001).
Schors, S.T., et al., “Role of the Vaccinia Virus E3L and K3L Gene Products in Rescue of VSV and EMCV from the Effects of IFN-α, ”Journal of Interferon and Cytokine Research, 18:721-729 (1998).
Uvarova, E.A. and Shchelkunov, S.N., “Species-Specific Differences in the Structure of Orthopoxvirus Complement-Binding Protein,”Virus Research, 81:39-45 (2001).

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