Method of inhibiting parasitic activity

Details Method of inhibiting parasitic activity Method of inhibiting parasitic activity

1991-01-08

1992-09-29

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514558, 514560, A61K 3119

Patent

active

051514451

ABSTRACT:
A method of inhibiting parasitic activity is disclosed in which the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor of said parasite is inhibited by incorporating into said GPI anchor an oxy-substituted fatty acid analog in place of myristate. The inhibitory compounds ar C.sub.13 and C.sub.14 fatty acids or alkyl esters thereof in which a methylene group normally in carbon position 4 to 13 of said fatty acid is replaced with oxygen.

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Bryant et al, Proc. Natl. Acad. Sci. USA 86, 8655-8659 (1989).

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