Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-15
1999-12-14
Carr, Deborah D
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514430, 549 29, 549 78, 549 79, 549 80, 554 85, 554101, A01N 4306
Patent
active
060018690
ABSTRACT:
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.
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Englund Paul T.
Gokel George W.
Gordon Jeffrey I.
Carr Deborah D
Johns Hopkins University
Meyer Scott J.
Washington University
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