Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1995-01-26
1998-09-15
Feisee, Lila
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
436 63, 436501, C12N 500, C12N 506
Patent
active
058077456
ABSTRACT:
The present invention relates to a method of inhibiting (reducing or preventing) the interaction of a cell which bears a surface molecule that interacts with a ligand comprising a Le.sup.x core with its target ligand by contacting the cell with an inhibitor comprising a Lewis x (Le.sup.x) core. The invention further relates to a method of inhibiting (reducing or preventing) the interaction or adhesion of endothelial cells and/or platelets with leukocytes (i.e., white blood cells), especially with nonlymphocytic leukocytes such as neutrophils and monocytes, by contacting the endothelial cells and/or platelets with an inhibitor comprising a Le.sup.x core under conditions whereby adhesion is inhibited.
REFERENCES:
patent: 3928587 (1975-12-01), Sawyer
patent: 4344936 (1982-08-01), Soslau
patent: 4783330 (1988-11-01), Furie et al.
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 5045453 (1991-09-01), Katapodis
patent: 5143712 (1992-09-01), Brandley et al.
patent: 5198424 (1993-03-01), McEver
patent: 5211936 (1993-05-01), Brandley et al.
patent: 5378464 (1995-01-01), McEver
patent: 5428025 (1995-06-01), Brandley et al.
patent: 5464778 (1995-11-01), Cummings et al.
patent: 5470842 (1995-11-01), Brandley et al.
Corral, L., et al., "Requirement for Sialic Acid on Neutrophils in a GMP-140 (PADGEM) Mediated Adhesive Interaction With Activated Platelets," Biochem. Biophys. Res. Comm., 172(3):1349-1356 (1990).
Moore, K.L., et al., "GMP-140 Binds to a Glycoprotein Receptor on Human Neutrophils: Evidence for a Lectin-Like Interaction," J. Cell Biol., 112(3):491-499 (1991).
Johnston, G.I., et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation," Cell, 56:1033-1044 (1989).
Skinner, M.P., et al., "Characterization of Human Platelet GMP-140 as a Heparin-Binding Protein," Biochem. Biophys. Res. Commun., 163(3):1373-1379 (1989).
Larsen, E., et al., "PADGEM Protein: A Receptor That Mediates the Interaction of Activated Platelets with Neutrophils and Monocytes," Cell, 59:305-312 (1989).
Hamburger, S.A. and McEver, R.P., "GMP-140 Mediates Adhesion of Stimulated Platelets to Neutrophils," Blood, 75(3):550-554 (1990).
Geng, J-G., et al., "Rapid Neutrophil Adhesion to Activated Endothelium Mediated by GMP-140," Nature, 343:757-760 (1990).
Larsen, E., et al., "PADGEM-Dependent Adhesion of Platelets to Monocytes and Neutrophils is Mediated by Lineage-Specific Carbohydrate, LNF III (CD15)," Cell, 63:467-474 (1990).
Marx, J.L., "New Family of Adhesion Proteins Discovered," Science, 234:1144 (1989).
Ohmori, K., et al., "Sialyl SSEA-1 Antigen as a Carbohydrate Marker of Human Natural Killer Cells and Immature Lympnoid Cells," Blood, 74(1):255-261 (1989).
Parmentier, S., et al., "New Families of Adhesion Molecules Play a Vital Role in Platelet Functions," Immunol. Today, 11(7):225-227 (1990).
Springer, T.A. and Lasky, L.A., "Sticky Sugars for Selections," Nature, 349:196-197 (1991).
Brandley, B.K., et al., "Carbohydrates Ligands of the LEC Cell Adhesion Molecules," Cell, 63:861-863 (1990).
Osborn, L., "Leukocyte Adhesion to Endothelium in Inflammation," Cell, 62:3-6 (1990).
Stoolman, L.M., "Adhesion Molecules Controlling Lymphocyte Migration," Cell, 56:907-910 (1989).
Tiemeyer, M., et al., "Identification and Structural Determination of an Endogenous Carbohydrate Ligand for ELAM-1," J. Cell. Biol., 111(5) (part 2): 159a, abstract No. 871 (1990).
Tiemeyer, M., et al., "Carbohydrate Ligand for Endothelial-Leukocyte Adhesion Molecule 1," Proc. Natl. Acad. Sci. USA, 88:1138-1142 (1991).
Walz, G., et al., "Recognition by ELAM-1 of the Sialyl-Le.sup.x Determinant on Myeloid and Tumor Cells," Science, 250:1132-1135 (1990).
Phillips, M.L., et al., "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le.sup.x," Science, 250:1130-1132 (1992).
Lowe, J.B., et al., "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA," Cell, 63:475-484 (1990).
Goelz, S.E., et al., "ELFT: A Gene That Directs the Expression of an ELAM-1 Ligand," Cell, 63:1349-1356 (1990).
Rice, G.E. and Bevilacqua, M.P., "An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion," Science, 246:1303-1306 (1989).
Hession, C., et al., "Endothelial Leukocyte Adhesion Molecule 1: Direct Expression Cloning and Functional Interactions," Proc. Natl. Acad. Sci. USA, 87:1673-1677 (1990).
Shimizu, Y., et al., "Activation-Independent Binding of Human Memory T Cells to Adhesion Molecule ELAM-1," Nature, 349:799-802 (1991).
Sherman-Gold, R., Genentech's Deal with Glycomed Illustrates Industry's Rising Interest in Glycobiology, Genetic Engineering New, Feb., 1991, at 1, col. 3.
Zhou, Q., et al., "The Selection GMP-140 Binds to Sialylated, Fucosylated Lactosaminoglycans on Both Myeloid and Nonmyeloid Cells," J. Cell. Biol., 115(2):557-564 (1991).
Polley, M.J., et al., "CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, Sialyl-Lews x," Proc. Natl. Acad. Sci. USA, 88:6224-6228 (1991).
Celi, A., et al., "PADGEM: An Adhesion Receptor for Leukocytes on Stimulated Platelets and Endothelial Cells (43309A)," Proc. Soc. Exp. Med., 198(2):703-709 (1991).
Moore, K.L. and R.P. McEver, "Analysis of Granule Membrane Protein-140 Binding to its Putative Neutrophil Receptor", Clinical Research, 38(2):364A (1990).
Kieffer, N. and D.R. Phillips, "Platelet Membrane Glycoproteins: Functions in Cellular Interactions", Annu. Rev. Cell Biol., 6:329-57 (1990).
Parmentier, S., et al., "Inhibition of Platelet Functions by a Monoclonal Antibody (LYP20) Directed Against a Granule Membrane Glycoprotein (GMP-140/PADGEM)", Blood, 77(8):1734-1739 (1991).
Fukuda, M., et al., "Structure of Sialylated Fucosyl Lactosaminoglycan Isolated from Human Granulocytes", Journal of Biological Chemistry, 259(17):10925-10935 (1984).
Mulligan, M.S., et al., "Protective effects of oligosaccharides in P-selectin-dependent lung injury", Nature, 364:149-151 (1993).
Palabrica, T., et al., "Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets", Nature, 359:848-851 (1992).
Stryer, L., Biochemistry, Second Edition, (W.H. Freeman: San Francisco), pp. 200-202 (1981).
Philips, M.R. et al., "Up-regulation of the iC3b Receptor (CR3) is Neither Necessary Nor Sufficient to Promote Neutrophil Aggregation", J. Clin. Invest., 82: 495-501 (1988).
Chemical Abstracts, entry for Registry No. 9072-19-9 (1995).
Patankar, M.S., "A Revised Structure for Fucoidan May Explain Some of Its Biological Activities", J. Biol. Chem., 268(29): 21770-21776 (1993).
Nishino, T. et al., "Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan", Carbohydrate Research, 255: 213-224 (1994).
Gooi, H.C. et al., "Stage-specific embryonic antigen involves .alpha.1.fwdarw.3 fucosylated type 2 blood group chains", Nature, 292: 156-158 (1981).
Han, K.T., et al., "Sialyl Lewis.sup.x Oligosaccharide Reduces Ischemia-Reperfusion Injury in the Rabbit Ear," J. Immunol., 155:4011-4015 (1995).
Tuomanen, E., "A Spoonful of Sugar to Control Inflammation," J. Clin. Invest. 93:917-918 (1994).
Forsyth, K.D, et al., "CD15 Antibodies Increase Neutrophil Adhesion to Endothelium by an LFA-1-Dependent Mechanism," Eur. J. Immunol, 19:1331-1334 (1989).
Carlos, T.M. and Harlan, J.M., "Membrane Proteins Involved in Phagocyte Adherence to Endothelium," Immunol. Reviews, 1145-28 (1990).
Albrechtsen, M. and Kerr, M.A., "Characterization of Human Neutrophil Glycoproteins Expressing the CD15 Differentiation Antigen (3-fucosyl-N-acetyllactosamine)," British J. of Heamat., 72:312-320 (1989).
Mulligan, M.S., et al., "Neutrophil-Dependent Acute Lung Injury," J. Clin. Invest., 90:1600-1607 (1992).
Edington, S.M., "How Sweet It Is: Selectin-Mediating Drugs", Biotechnology, 10:383-389 (1992).
Gooi et al., Eur. J. Immunol. 13: 306-312 (1983).
Furie Barbara C.
Furie Bruce
Larsen Eric
Palabrica Theresa
Sajer Susan A.
Feisee Lila
Gambel Phillip
New England Medical Center Hospitals Inc.
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