Method of inhibiting P-selectin ligand activity

Details Method of inhibiting P-selectin ligand activity Method of inhibiting P-selectin ligand activity

1995-06-07

1998-11-24

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4241441, 435 71, 53038822, A61K 3816, A61K 39395, G01N 3353, C07K 1600

Patent

active

058406794

ABSTRACT:
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

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