Method of inhibiting oxidants using alkylaryl polyether alcohol

Details Method of inhibiting oxidants using alkylaryl polyether alcohol Method of inhibiting oxidants using alkylaryl polyether alcohol

1994-03-29

1995-12-12

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 7837, 514828, 514851, A61K 912, A61K 31765

Patent

active

054747600

ABSTRACT:
A method and medicament for the inhibition of oxidants comprising administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. The medicament is preferably administered by aerosolization into the mammalian respiratory system. The medicament may also be applied to the mammalian skin. Preferably, the medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, isotonic saline, normal saline, petrolatum based ointments and U.S.P. cold cream.

REFERENCES:
Robert A. Greenwald, CRC Handbook of Methods for Oxygen Radical Research; Determination of HOCl Production by Micloperoxidase; p. 300 (1987).
Cantin et al.; The Journal of Clinical Investigation, Inc. Protection by Antibiotics agains Myeloperoxidase-dependent Cytotoxicity to Lung Ephithelial Cells in Vitro; vol. 91, pp. 38-45 (Jan., 1993).
Ramsey, et al. The New England Journal of Medicine; Efficacy of Aerosolized Tobramycin in Patients with Cystic Fibrosis; vol. 328 No. 24 pp. 1740-1746 (Jun. 17, 1993).
Vasconcellos, et al. Science; Reduction in Viscosity of Cystic Fibrosis Sputum in Vitro by Gelsolin; vol. 263, pp. 969-971 (Feb. 18, 1994).

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