Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-02-14
1999-07-13
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3135
Patent
active
059227567
ABSTRACT:
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which include catechin derivatives and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a catechin derivative, such as epigallocatechin-3-gallate or a related polyphenol, in pure form or in a pharmaceutically acceptable carrier. The novel inhibitors inhibit nitric oxide synthase at the level of gene expression and enzyme activity.
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