Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-02-05
1998-11-17
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31155
Patent
active
058377387
ABSTRACT:
A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal afflicted with an acute or chronic inflammatory disease which comprises administering to said mammal an effective nitric oxide inhibitory amount of methyl-, or 1,1-dimethyl-, or amino-substituted guanidines.
REFERENCES:
patent: 3541218 (1970-11-01), Marshall et al.
patent: 4758583 (1988-07-01), Cerami et al.
patent: 4870210 (1989-09-01), Musser
patent: 5128360 (1992-07-01), Cerami et al.
patent: 5246970 (1993-09-01), Williamson et al.
patent: 5246971 (1993-09-01), Williamson et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5317040 (1994-05-01), Goldman et al.
patent: 5358969 (1994-10-01), Williamson et al.
patent: 5449688 (1995-09-01), Wahl et al.
Henrichs (1990), Pharm. Ztg. 135:1711-24.
Vissara (1990), Chronic Diabetic Complications and Tissue Glycosylation Relevant Concern for Diabetes-Prone Black Population, Diabetes Care 13:1180-5.
Kieronska et al. (1978), The Influence of Aminoguanidine Derivatives on the Process of Humoral and Cellular Immunogenesis, Achivum Immunologiae 26:959-62.
Bach, 1994, Endocrine Rev. 15:516-42.
Masferrer et al., 1994, Proc. Natl. Acad. Sci. USA 91:3228-32.
Salvemini et al., 1994, J. Clin. Invest. 93:1940-47.
Corbett et al., 1993, Autoimmunity 15:145-53.
Corbett et al., 1993, Biochemistry 32:13767-70.
Corbett et al., 1992, Biochem. J. 287:229-35.
Fletcher et al., 1992, J. Biol. Chem. 267:4338-44.
Bucala et al., 1991, J. Clin. Invest. 87:432-38.
Ialenti et al., 1992, European J. Pharmacol. 211:177-82.
Kihara et al., 1991, Proc. Natl. Acad. Sci9. USA 88:6107-11.
Pugliese et al., 1991, Diabetes/Metabolism Rev. 7:35-59.
Stuehr et al., 1991, Proc. Natl. Acad. Sci. USA 88:7773-77.
Southern et al., 1990, FEBS. Lett. 276:42-44.
Hibbs et al., 1990, Nitric Oxide from L-Arginine: A Bioregulatory System, Moncada and Higgs, Eds., Elsevier, NY, pp. 189-223.
Williamson et al., 1990, Diabete & Metab. 16:369-70.
Brownlee et al., 1988, New Engl. J. Med. 318:1315-21.
Herbort et al., 1988, Graefe's Arch. Clin. Exp. Ophthalmol. 226:553-58.
Brownlee et al., 1986, Science 232:1629-32.
Cousins et al., 1984, Exp. Eye Res. 39:665-26.
Corbett John A.
McDaniel Michael L.
Tilton Ronald G.
Williamson Joseph R.
Henley III Raymond
Washington University
LandOfFree
Method of inhibiting nitric oxide formation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inhibiting nitric oxide formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inhibiting nitric oxide formation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-884842