Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-10-21
1993-12-14
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514469, A61K 3134
Patent
active
052703355
ABSTRACT:
A method of inhibiting the metabolism of cholesterol, comprising administering to a subject a pharmaceutical composition comprising a dioxabicyclo[3.3.0]octane derivative represented by the following general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R.sup.1 and R.sup.2 and/or R.sup.4 and R.sup.5 together form a methylene group or an ethylene group, and n, m and l are 0 or 1.
REFERENCES:
Nobuaki Hirose et al., "Inhibition of cholesterol absorption and synthesis in rats by sesamin," Journal of Lipid Research, vol. 32, 1991, pp. 629-638.
Michihiro Sugano et al., "Influence of Sesame Lignans on Various Lipid Parameters in Rats," Agric. Biol. Chem., 54(10), 1990, 2669-2673.
Patent Abstracts of Japan, vol. 13, No. 326 (C-620) [3674], Jul. 24, 1989.
The Merck Index, #8418, 11th Ed., 1989.
CA 114(1):5257w, Sugano et al., 1990.
Akimoto Kengo
Asami Sumio
Hirose Nobuaki
Sugano Michihiro
Jordan Kimberly R.
Suntory Limited
Waddell Frederick E.
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