Method of inhibiting lipofibroblast to myofibroblast...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S369000, C514S374000, C514S462000, C514S568000, C514S573000, C514S619000, C514S635000

Reexamination Certificate

active

06992093

ABSTRACT:
Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.

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Rehan et al., FASEB Journal, (Mar. 22, 2002) vol. 16, No. 5, pp. A1151.
Demayo et al. (2002) “Mesenchymal-epithelial interaction in lung development and repair: are modeling and remodeling the same process” AJP Lung Cellular and Molecular Physiology vol. 283: Issue 3: pp. 510-517.
Torday et al. (2003) “Mechanotransduction determines the structure and function of lung and bone” Cell Biochemistry and Biophysics, vol. 37, pp. 235-246.
Torday et al. (2003) “The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation and in vitro” Ped, Pathol Mol Med vol. 3, pp. 189-207.

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