Method of inhibiting intimal hyperplasia

Details Method of inhibiting intimal hyperplasia Method of inhibiting intimal hyperplasia

1996-09-25

1999-06-22

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, A61K 3800

Patent

active

059143169

ABSTRACT:
A method is disclosed for inhibiting intimal hyperplasia in a warm-blooded mammal which comprises administering topically at the site and time of a vascular injury induced by arterial intervention in said mammal a small but inhibitorily effective amount of tissue factor pathway inhibitor (TFPI) sufficient to inhibit said intimal hyperplasia.

REFERENCES:
patent: 4966852 (1990-10-01), Wun et al.
patent: 5106833 (1992-04-01), Broze et al.
patent: 5212091 (1993-05-01), Diaz-Collier et al.
patent: 5276015 (1994-01-01), Khouri et al.
patent: 5385885 (1995-01-01), Gask et al.
U.S. application No. 08/093,285, Abstract, G.J. Broze, filed Jul. 23, 1987.
Broze and Miletich, Proc.Natl.Acad.Sci. U.S.A. 84, 1886-1890 (1987).
Novotny et al, J.Biol.Chem. 264, 18832-18837 (1990).
Wun et al, J.Biol.Chem. 265, 16096-16101 (1990).
Wun et al, J.Biol.Chem. 263, 6001-6004 (1990).
Girard et al, Thromb.Res.55, 37-50 (1989).
Girard et al, Nature 328, 518-520 (1989).
Rapaport, Blood 73, 259-365 (1989).
Broze et al., Biochemistry 29, 7539-7546 (1990).
Day et al, Blood 76, 1538-1545 (1990).
Pedersen et al, J.Biol.Chem. 265, 16786-16793 (1990).
Haskel et al, Circulation 84, 821-827 (1991).
Wun et al, Thromb.Hemostat. 68, 54-59 (1992), Cold Spring Lab.
Sprecher et al, Proc.Natl.Acad.Sci. USA 91, 3353-3357 (1994).
Cooley & Hansen, Microsurgery 6 (46-48,(1985).
Cooley & Gould, Microsurgery 12, pp. 281-287 (1991).
Broze et al., Biochemistry 29, 7539-7546 (1990).

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