Method of inhibiting interleukin-1 release

Details Method of inhibiting interleukin-1 release Method of inhibiting interleukin-1 release

1988-02-18

1989-09-26

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

A61K 3127

Patent

active

048701017

ABSTRACT:
Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceutically acceptable antioxidant compound such as disulfiram, tetrakis [3-(2,6-di-tert-butyl-4-hydroxyphenyl)propionyloxy methyl]methane or 2,4-di-isobutyl-6-(N,N-dimethylaminomethyl)-phenol.

REFERENCES:
Marx, Science, 239, 257-258 (1988).
Libby et al., Fed. Proc., 46, No. 3, 975, Abstract 3837 (1987).
Pukel et al., Diabetes, 37, 133-136 (1988).
Mandrup-Poulsen et al., J. Immunol., 139, 4077-4082 (1987).

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