Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-04-30
1997-04-01
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 46, 536 2626, 536 276, A61K 3170, C07H 19173, C07H 1920
Patent
active
056165668
ABSTRACT:
A method for inhibiting intracellular replication of HIV in an HIV-infected individual comprising contacting the HIV reverse transcriptase in the HIV-infected cells with 2',3'-dideoxyadenosine-5'-triphosphate whose source is 2',3'-dideoxyadenosine or a pharmaceutically acceptable salt or prodrug thereof.
REFERENCES:
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 4081534 (1978-03-01), Elion et al.
patent: 4434788 (1984-03-01), Nakatsugawa
patent: 4481197 (1984-11-01), Rideout et al.
patent: 4577012 (1986-03-01), Tsurushima et al.
patent: 4861759 (1989-08-01), Mitsuya et al.
patent: 4920210 (1990-04-01), Koszalka et al.
patent: 5026687 (1993-10-01), Yarchoan et al.
patent: 5254539 (1993-10-01), Mitsuya et al.
Cheng et al., 1987, "Human Immunodeficiency Virus Reverse Transcriptase," J. Biol. Chem. 262 (No. 5): 2187-2189.
Mitsuya et al., Oct. 1985, "3'-Azido-3'-Deoxythymidine (BW A509U): An Antiviral Agent That Inhibits The Infectivity And Cytopathic Effect Of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus In Vitro", Proc. Natl. Acad. Sci. USA 82: 7096-7100.
Mitsuya et al., 1986, "Inhibition Of The In Vitro Infectivity And Cytopathic Effect Of Human T-Lymphotrophic Virus Type III/Lymphadenopathy-Associated Virus (HTLV-III/LAV) By 2',3'-Dideoxynucleosides," Proc. Natl. Acad. Sci. USA 83: 1911-1915.
Furmanski et al., 1980, Inhibition by 2',3'-Dideoxythymidine of Retroviral Infection of Mouse and Human Cells. Cancer Letters, 8:307-315.
Ho et al., 1985, Recombinant Human Interferon Alfa-A Supresses HTLV-III Replication In Vitro. Lancet i:602-604.
Martin et al., 1987, Synthesis and Antiviral Activity of Various Esters of 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine. J. Pharmaceutical Sciences, 76(2):180-184.
McCormick et al., 1984, Ribavirin Suppresses Replication of Lymphadenopathy-Associated Virus in Cultures of Human Adult T-lymphocytes, Lancet ii:1367-1369.
Mitsuya et al., 1984, Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III. Science, 226:172-174.
Mitsuya et al., 1985, Protection of T Cells Against Infectivity and Cytopathic Effect of HTLV-III In Vitro. Retroviruses in Human Lymphoma/Leukemia, M. Miwa et al. (Eds.), Japan Sci. Soc. press., 277-288.
Mitsuya et al., 1987, Rapid In Vitro Systems For Assessing Activity of Agents Against HTLV-III/LAV. Ch. 18 AIDS: Modern Concepts and Therapeutic Changes, Broder (Eds.), 303-333.
Prisbe et al., 1985, A Novel and Efficient Preparation of 2',3'-Dideoxynucleosides. Synthetic Communications, 15(5):401-409.
Rozenbaum et al., 1985, Antimoniotungstate (HPA23) Treatment of Three Patients With AIDS and One With Prodrome. Lancet i:450-451.
Sandstrom et al., 1985, Inhibition of Human T-cell Lymphotropic Virus Type III in Vitro By Phosphonoformate. Lancet i:1480-1482.
Sandstrom et al., 1987, Antiviral Therapy in AIDS Clinical Pharmacological Properties and Therapeutic Experience to Date. Drugs, 34:372-390.
Stoeckler et al., 1980, Human Erythrocytic Purine Nucleoside Phosphorylase: Reaction with Sugar-Modified Nucleoside Substrates, Biochemistry, 19:102-107.
Waqar et al., 1984, Effects of 2',3'-Dideoxynucleosides on Mammalian Cells and Viruses, J. Cellular Physiol., 121:402-408.
Yarchoan et al., 1987, Strategies For the Pharmacological Intervention Against HTLV-III/LAV. Ch. 19 AIDS: Modern Concepts and Therapeutic Challenges, Broder (Eds.), 335-360.
Lehninger, Albert L. Biochemistry, Second Edition, Worth Publishers, Inc., 1975, pp. 741, 184, and 218.
Broder Samuel
Mitsuya Hiroaki
Yarchoan Robert
Kunz Gary L.
The United States of America as represented by the Department of
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