Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-12
1995-12-05
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546242, A61K 31445, C07D21146
Patent
active
054729696
ABSTRACT:
A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
REFERENCES:
patent: 4065562 (1977-12-01), Ohata et al.
patent: 4182767 (1980-01-01), Murai et al.
patent: 4533668 (1985-08-01), Matsumara et al.
patent: 4639436 (1987-01-01), Junge et al.
patent: 4849430 (1989-07-01), Fleet et al.
patent: 5011829 (1991-04-01), Hirsch et al.
patent: 5030638 (1991-07-01), Partis et al.
Chemical Abstracts: 115:250930 "Human Acid .beta.-glucosidase, etc." Fabbro et al. J. Biol Chem (1991) 266(23) 15021-7.
Chemical Abstracts: 110:91215 "Human Acid .beta.-glucosidase, etc." Osiecki-Newman, et al., Enzyme (1988), 40(4), 173-88.
Chemical Abstracts: 108:18433 "Human Acid .beta.-glucosidase, etc." Osiecki-Newman, et al., Biochim. Biophys. Acta, (1987) 915(1), 87-100.
Saunier et al., J. Biol. Chem. 257, 14155-14161 (1982).
Elbein, Ann. Rev. Biochem. 56, 497-534 (1987).
NewBrun, Arch. Oral Biol. 28, 531-536 (1982).
Wang et al., Tetrahedron Lett. 34, 403-406 (1993).
Karlsson et al., J. Biol. Chem. 268, 570-576 (1993).
Shukla et al., Biochem. Biophys. Acta 1083, 101-108 (1991).
Shukla and Radin, J. Lipid Res. 32, 713-722 (1991).
Basu, J. Biol. Chem. 248, 1388-1394 (1973).
van Heyningen, Nature 249, 415-417 (1974).
Karlsson, Ann. Rev. Biochem. 58, 309-350 (1989).
Platt et al., Eur. J. Biochem. 208, 187-193 (1992).
Butters and Hughes, In Vitro 17, 831-838 (1981).
Butters Terry D.
Dwek Raymond A.
Neises Gabrielle R.
Platt Frances M.
Meyer Scott J.
Monsanto Company
O'Sullivan Peter
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