Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone a

Details Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone a Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone a

1997-03-20

1999-12-21

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514345, 514348, 514349, 514351, 514352, 514357, A61K 3144, A61K 31165

Patent

active

060050098

ABSTRACT:
Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone, 3-hydroxyisonicotinaldehyde benzoyl hydrazone and salicylaldehyde benzoyl hydrazone. The methods are useful in treating fibrosing disorders, including dermal fibrosing disorders, fibrosis of internal organs and fibrotic conditions of the eye.

REFERENCES:
Khaidarly, I.N., Probl. Tuberk., 48(3), 82-6 (abstract), 1970.

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