Method of inhibiting fibrinogen binding to endothelial cells wit

Details Method of inhibiting fibrinogen binding to endothelial cells wit Method of inhibiting fibrinogen binding to endothelial cells wit

1996-11-12

1999-07-06

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 13, 514885, 514 12, 530324, 530325, 530326, 530382, A61K 3802, A61K 3817

Patent

active

059197544

ABSTRACT:
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

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