Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-05-24
2005-05-24
Chen, Shin-Lin (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
06897197
ABSTRACT:
The present invention provides a novel method of inhibiting the growth of tumor cells based upon the discovery that p19ARFacts as a suppressor of oncogenic transformation by binding to the MDM2 oncoprotein and blocking MDM2's ability to target associated proteins, such as p53 and Rb, for proteosomal degradation. The method provided by the present invention inhibits the growth of a tumor cell by administering to the cell an effective amount of p19ARFor a mimetic thereof, and p53 to inhibit the growth of the tumor cell. Also provided by the present invention are pharmaceutical composition comprising p19ARFor a mimetic thereof, and/or p53.
REFERENCES:
patent: 5411860 (1995-05-01), Vogelstein et al.
patent: 5672508 (1997-09-01), Gyuris et al.
patent: 5702908 (1997-12-01), Picksley et al.
Quelle et al., Cloning and characterization of murine p 16INKa and p 15INK4b genes, Oncogene, 11(4): 635-645, Aug. 1995.
Quelle et al., Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest, Cell, 83: 993-1000, Dec. 1995.
Sherr, C.J., Cancer Cell Cycles, Science, 274: 1672-1677, 1996.
Serrano et al., Role of INK4a Locus in Tumor Suppression and Cell Mortality, Cell, 85(1): 27-37, 1996.
Quelle et al., Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARFProc. Natl. Acad. Sci. U.S.A., 94(2): 669-673, 1997.
J. Rudinger, Peptide Hormones, Edited by Oarsons, University Park Press, Baltimore, p. 1-7, 1976.
Eck et al., Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, McGraw-Hill, New York, p. 77-101, 1996.
Kamijo et al., Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19arf, 1997, Cell, vol. 91, p. 649-659.
Kaye et al., A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding, 1990, Proc. Natl. Acad. Sci., vol. 87: 6922-6926.
Verma et al., Gene therapy-promises, problems, and prospects, 1997, Nature, vol. 389: 239-242.
Crystal: Transfer of Genes to Humans: Early Lessons and Obstacles to Success, 1995, Science, vol. 270: 404-410.
Deonarain; Ligand-targeted receptor-mediated vectors for gene delivery, 1998, Exp. Opin. Ther. Patents 8(1): 53-69.
Albert Einstein College of Medicine of Yeshiva University
Amster Rothstein & Ebenstein LLP
Chen Shin-Lin
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