Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-12-09
2000-07-04
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 53, 514 23, 514 61, 536 187, 5361231, A61K 31715
Patent
active
060839317
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to an anticancer agent for remarkably inhibiting the metastasis of cancer cells, and is aimed at providing a medicine which can completely cure a cancer by inhibiting the metastasis of the cancer cells.
BACKGROUND TECHNIQUE
In order to treat cancers, there have been recently adopted chemical therapy using various anticancer agents, immunotherapy for promoting the production of antibodies against cancer cells, surgical therapy for extracting cancer cells, radiotherapy for killing cancer cells by irradiation, etc. However, as these therapies have been developed, the surgical operations or radiotherapy technically suffer their limits, and cannot effectively inhibit the metastasis of the cancers. On the other hand, although the chemical therapy directly acts upon the cancer cells with use of the anticancer agents, many of the anticancer agents then cause harmful side effects even upon normal cells of a host. Therefore, the chemical therapy is not necessarily effective for the metastasis of the cancer. Further, no excellent effects against the metastasis of the cancers have not been seen in the case of the immunotherapy which is to treat the cancer. Although the therapeutic effects against original cancers have been largely enhanced, not a few patients become dead by metastasized cancers provoked by the metastasis of cancer cells, even if the original cancers are completely cured. In order to inhibit the metastasis of the cancers, there has strongly demanded development of medicines for inhibiting the metastasis of cancer cells. It is considered that the cancer cells metastasize over a wide area through being adhered to cell membranes of tissues such as mesenteries.
Although it is recognized that a medicine for inhibiting the metastasis of cancer cells has an effect to inhibit the metastasis of the cancer cells when sizofiran is used in combination with a chemotherapy agent, a medicine has not been commercially available to inhibit the metastasis of cancer cells when used alone. Further, although JP-A 60-190,791, JP-A 61-83,125 and JP-A 62-223,124 disclose cancer metastasis-inhibiting actions with sialic acid derivatives, they fail to describe sialic acid or its derivative used as an effective ingredient in the present invention or the cancer metastasis-inhibiting action thereof.
PROBLEMS TO BE SOLVED
In view of the above problems, the present invention is aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells when used alone. In addition, the present invention is also aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells while causing a small side effect and very small toxicity even for an extended time of administration.
The present invention has been accomplished through screening medicines capable of inhibiting the metastasis of cancer cells from the natural sphere, and relates to an anticancer agent having sialic acid and/or its salt as an effective ingredient and exhibiting a cancer metastasis-inhibiting action.
The present invention also relates to an anticancer agent having a polymer of sialic acid and/or a salt of the polymer as an effective ingredient and exhibiting a cancer metastasis-inhibiting action.
It is preferable that the polymer of sialic acid is a polymer composed of two to thirteen moles of sialic acid. The reason why the upper limit is set upon a thirteen molecule polymer is that it is possible to effectively fraction and separate up to the thirteen molecule polymers. It is expected that the sialic acid polymers composed of two to thirteen molecules of sialic acid and the salts thereof have pharmacological effects similar to those of sialic acid and its salt. As the salts of sialic acid and its polymers, various pharmaceutically allowable salts may be used. As the salts of a monomer of sialic acid, a sodium salt, a potassium salt, a calcium salt, and a magnesium salt may be used. As the salts of the polymers of sialic acid, sodium salts may be used. "Sialic acid" r
REFERENCES:
The Merck Index, Ninth Edition, 1976, Merck & Co., Inc., Rahway, NJ, monograph 8225, p, 1098.
Kovacs et al. Thrombosis and Haemostasis (Stuttgart) 1979. 42(4), 1187-92.
McGuire et al. Biochemistry Feb. 1964, 3(2), 247-251.
Kimura et al. Fukushima Journal of Medical Science 1968, 15(1-2), 55-60.
XP-002102509 Polemical Review, Schirrmacher et al., "Importance of Cell Surface Carbohydrates in Cancer Adhesion, Invasion and Metastasis, vol. 2, No. 6, 1982, pp. 313-360.
XP-002102510 Abstract; Derwent AN 94-321291; 9-6-94.
Hasegawa Takaaki
Inukai Tadahiko
Kawase Mitsuo
Miyamoto Ken'ichi
Yoshida Yasuko
Biseiken Co., Ltd.
Fonda Kathleen K.
NGK Insulators Ltd.
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