Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
Patent
1997-01-15
1998-11-17
Huff, Sheela
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
514153, 514154, A01N 3718, A61K 3165
Patent
active
058376968
ABSTRACT:
The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.
REFERENCES:
patent: 5308839 (1994-05-01), Golub et al.
patent: 5321017 (1994-06-01), Golub et al.
patent: 5563130 (1996-10-01), Backer
patent: 5567693 (1996-10-01), Backer et al.
patent: 5574026 (1996-11-01), Backer et al.
patent: 5668122 (1997-09-01), Fife et al.
Bassett P, Okada A, Chenard M-P, Kannan R, Stoll I, Anglard P, Bellocq J-P, Rio M-C, "Matrix Metalloproteinases as Stromal Effectors of Human Carcinoma Progression: Therapeutic Implications", Matrix Biology 15:535-541 (1997).
Golub LM, Ramamurthy NS, Leungt M, McNamara TF, "Low-Dose Doxycycline Thrapy: Effect on Gingival and Crevicular Fluid Collagenase Activity in Humans", J. Periodont Res 25:321-330 (1990).
Golub LM, Lee HM, Lehrer G, Nemiroff A, McNamara TF, Kaplan R, Ramamurthy NS, "Minocycline Reduces Gingival Collagenolytic Activity During Diagetes", Journal of Periodontal Research 18:516-526 (1983).
Hatsu M, Sasaki T, Watabe H-O, Miyadoh S, Nagasawa M, Shomura T, Sezaki M, Inouye S, Kondo S, "A New Tetracycline Antibiotic with Antitumor Activity", The Journal of Antibiotics 45(3):320-324 (1992).
Hatsu M, Sasaki T, Gomi S, Kodama Y, Sezaki M, Inouye S, Kondo S, "A New Tetracycline Antibiotic with Antitumor Activity", The Journal of Antibiotics 45(3):325-330 (1992).
Johnson RK, Goldin A, "The Clinical Impact of Screening and Other Experimental Tumor Studies", Cancer Treatment Reviews 2:1-31 (1975).
Okada A, Bellocq J-P, Rouyer N, Chenard M-P, Rio M-C, Chambon P, Basset P, "Membrane-Type Matrix Metalloproteinase (MT-MMP) Gene is Expressed in Stromal Cells of Human Colon, Breast, and Head and Neck Carcinoma", Proc. Natl. Acad. Sci. USA 92:2730-2734 (1995).
Okada A, Tomasetto C, Lutz Y, Bellocq J-P, Rio M-C, Basset P, "Expression of Matrix Metalloproteinases During Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase is a Stromal Activator of Pro-Gelatinase A", The Journal of Cell Biology 137(1):67-77 (1997).
Sotomayor EA, Teicher BA, Schwartz GN, Holden SA, Menon K, Herman TS, Frei III E, Minocycline in Combination with Chemotherapy or Radiation Therapy in Vitro and in Vivo, Cancer Chemother Pharmacol 30:377-384 (1992).
Uitto V-J, Firth JD, Nip L, Golub LM "Doxycycline and Chemically Modified Tetracyclines Inhibit Gelatinase A (MMP-2) Gene Expression in Human Skin Keratinocytes", Annals of the New York Academy of Sciences 732:140-151 (1994).
Zeng ZS, Huang Y, Cohen AM, Guillem JG, "Prediction of Colorectal Cancer Relapse and Survival via Tissue RNA Levels of Matrix Metalloproteinase-9", Journal of Clinical Oncology 14(12):3133-3140 (1996).
Zucker S. Lysik RM, Ramamurthy NS, Golub LM, Wieman JM, Wilkie DP, "Diversity of Melanoma Plasma Membrane Proteinases: Inhibition of Collagenolytic and Cytolytic Activities by Minocycline", JNCI 75(3):517-525 (1985).
Zucker S, Turpeenniemi-Hujanen, T, Ramamurthy N, Wieman J, Lysik R, Gorevic P, Liotta LA, Simon SR, Golub LB, "Purification and Characterization of a Connective-Tissue-Degrading Metalloproteinase from the Cytosol of Metastatic Melanoma Cells", Biochem. J 245:429-437 (1987).
Zucker S, Weiman J, Lysik RM, Imhof B, Nagase H, Ramamurthy N, Liotta LA, Golub LM, "Gelatin-Degrading Type IV Collagenase Isolated from Human Small Cell Lung Cancer", Invasion Metastasis 9:167-181 (1989).
Johnson et al, Cancer Treatment Reviews vol. 2 p. 1, 1975.
Block Norman L.
Golub Lorne M.
Lee Hsi-Ming
Lokeshwar Balakrishna L.
McNamara Thomas F.
Huff Sheela
The Research Foundation of State University of New York
University of Miami
LandOfFree
Method of inhibiting cancer growth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inhibiting cancer growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inhibiting cancer growth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-884589