Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1992-11-16
1995-08-01
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241401, 4241411, 53038823, 53038824, 53038825, 604 4, A61K 39395, G07K 1528
Patent
active
054378648
ABSTRACT:
This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods.
REFERENCES:
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Tanaka, H., et al., Thrombosis Res. 40: 745-756 (1985).
Kohler, G., et al., Nature 256: 495-497 (Aug. 7, 1975).
Carson, et al., Monoclonal Antibodies Against Bovine Tissue Factor, Which ock Interaction with Factor VII, Blood, 66:152,156, 1985.
Guha, et al. Affinity Purification of Human Tissue Factor: Interaction of Factor VII and Tissue Factor in Detergent-Micelles, Proc. Natl. Acad. Sci. USA, 83:299-302, 1986, Biochemistry.
Yanina T. Wachtfogel, et al.,; Formation of Cl.sub.s -Cl-Inhibitor, Kallikrein . . . Blood; vol. 73, No. 2; Feb., 19889; pp. 468-471.
Janos Kappelmayer, et al.; Upregulation of Mac-1 surface expression . . . Mosby/Journal Page 1 Sep. 11, 1992.
Yanina T. Wachtfogel, et al., Human Neutrophil Degranulation During . . . Blood, vol. 69, No. 1 Jan. 1987 pp. 324-330.
Jacek Musial, et al.; Loss of Fibrinogen Receptors from the Platelet . . . The Journal of Laboratory and Clinical Medicine; vol. 105, No. 4, pp. 514-522.
Robert W. Colman, MD; Platelet and Neutrophil Activation in Cardiopulmonary . . . The Society of Thoracic Surgeons; 1990.
L. H. Edmunds, Jr., et al.; Blood-Surface Interactions During Cardiopulmonary . . . Steinkopff Verlag Darmstadt; 1991; pp. 27-36.
Bernabei Alvise
Colman Robert W.
Edgington Thomas S.
Edmunds, Jr. L. Henry
Kappelmayer Janos
Cunningham T.
Nucker Christine M.
Temple University - Of the Commonwealth Systems of Higher Educat
The Scripps Research Institute
Trustees of the University of Pennsylvania
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