Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Urogenital system
Patent
1997-11-26
1999-07-27
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Urogenital system
424568, 424571, 435184, 435190, A61K 3523, A61K 3555, A61K 3544, C12N 904, C12N 999
Patent
active
059286709
ABSTRACT:
An intrinsic aldose reductase inhibitor is isolated and purified from mammalian cells, such as rat or human kidney cells. The intrinsic aldose reductase inhibitor may be incorporated into pharmaceutical compositions for the treatment of certain conditions related to diabetes.
REFERENCES:
patent: 4382887 (1983-05-01), Shibata
patent: 5066676 (1991-11-01), Caccia et al.
patent: 5153211 (1992-10-01), York, Jr.
patent: 5155259 (1992-10-01), Suzuki et al.
patent: 5560936 (1996-10-01), Kador et al.
patent: 5738878 (1998-04-01), Kador et al.
Akagi Y., et al., The Prevention of the Rat Galactosemic Cataract With a New Aldose Reductase Inhibitor, OPQ (Oxazopyrroloquinoline) , Abstract, The Sixth Congress of the U.S. Japan, Cooperative Cataract Research Group (CCRG), Nov. 30-Dec. 5, 1991, Kona Surf Resort, Kona, Hawaii, USA, p. 200 (1991).
Beyer-Mears A. et al., "Comparison of Sorbinil and Ponalrestat (Statil) Diminution of Proteinuria in the BB Rat," Pharmacology, 1992, vol. 45, pp. 285-291.
Fukushi S. et al., "Aldose Reductase Inhibition by Pyrroloquinoline Quinone and Its Derivatives," Program & Abstract, International Workshop on Aldose Reductase Inhibitors, Dec. 7-10, 1987, Hilton Hawaiian Village Hotel, Honolulu, Hawaii, ICI Pharmaceuticals Group, Wilmington, DE, USA, Abstract C4.6, one page.
Kador Peter F. et al., "What is the Nature of the Charge Transfer Interaction at The Aldose Reductase Inhibitor Site," Enzymology and Molecular Biology of Carbonyl Metabolism 2, 1989, 290, pp. 237-250.
Kador Peter F., "Aldose Reductase Inhibitors," Current Concepts of Aldose Reductase and Its Inhibitions, Proceedings of the Japan-US Aldose Reductase Workshop, Nagoya, Japan, Nov. 16-17, 1989, Excerpta Medica, 1990, 913, pp. 73-79.
Kador Peter F. et al., "Intrinsic Inhibitor of Aldose Reductase (IARI), Its Isolation and Purification," Chemical Abstracts, Jun. 21, 1993, vol. 118, No. 25, 7-Enzymes, 118:25069q (25), p. 439, ISNN 0009-2258.
Murai H. et al., "Aldose Reductase Inhibitors of Microbial Origin," The Sixth Congress of the U.S. Japan Cooperative Cataract Research Group (CCRG), Nov. 30-Dec. 5, 1991, Kona Surf Kona, Hawaii, USA, Abstract, p. 190.
Mylari Banavara L. et al., "A Highly Specific Aldose Reductase Inhibitor, Ethyl 1-Benzyl-3-Hydroxy-2(5H)-Oxypyrrole-4Carboxylate, and Its Congeners," J. Med. Chem., 1991, vol. 34, No. 3, pp. 1011-1018.
Nishigori Hideo et al., "Preventive Effects of Pyrroloquinoline Quinone on Formation of Cataract and Decline of Lenticular and Hepatic Glutathione of Developing Chick Embryo After Glucocorticoid Treatment," Life Sciences, Jun. 1989, vol. 45, No. 7, pp. 593-598.
Notsu Y. et al., "Biochemical and Pharmacological Properties of a Novel Aldose Reductase Inhibitor, FR 74366," Program & Abstract, International Workshop on Aldose Reductase Inhibitors, Dec. 7-10, 1987, Hilton Hawaiian Village Hotel, Honolulu, Hawaii, ICI Pharmaceuticals Group, Wilmington, DE, USA, Abstract C4.5, one page.
Ohta Miyako et al., "Characterization of Aldose Reductase and Aldehyde Reductase from the Medulla of Rat Kidney," Chem. Phar. Bull., 1990, vol. 38, No. 6, pp. 1639-1643.
Reddy Venkat N. et al., "The Efficacity of Aldose Reductase Inhibitors on Polyol Accumulation in Human Lens and Retinal Pigment Epithelium in Tissue Culture," Journal of Ocular Pharmacology, Spring 1992, vol. 8, No. 1, George C. Y. Chiou Editor, pp. 43-52.
Sato Sanai et al., "Inhibition of Aldehyde Reductase by Aldose Reductase Inhibitors," Biochemical Pharmacology, 1990, vol. 40, No. 5, pp. 1033-1042.
Smar Michael W. et al., "Selective Irreversible Inhibitors of Aldose Reductase," J. Med. Chem., 1992, vol. 35, No. 6, pp. 1117-1120.
Federal Register, Pending Application No. 07/966,970, "Intrinsic Inhibitors of Aldose Reductase," vol. 58, No. 71, Thursday Apr. 15, 1993, Notices, p. 19655.
Kador Peter F.
Rodriguez Libaniel
Schaffhauser Matteo
Takahashi Yukio
Terada Tomoyuki
The Government of the United States of America as represented by
Weber Jon P.
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