Method of inhibiting abnormal tau hyper phosphorylation in a cel

Details Method of inhibiting abnormal tau hyper phosphorylation in a cel Method of inhibiting abnormal tau hyper phosphorylation in a cel

1995-06-07

1999-09-21

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, A01N 3170

Patent

active

059554444

ABSTRACT:
Novel TAU
eurofilament protein kinases, PK40 and PK36, are essentially purified and characterized. Novel immunoassays relating to the kinases and inhibitors for the kinases also are provided. Finally, DNA sequences encoding the kinases and cell lines relating to the kinases are provided. Methods of inhibiting abnormal tau HYPER PHOSPHORYLATION activity in a cell by contacting a cell with an inhibitor that binds to an ATP binding site of PK40, in an amount sufficient to inhibit said phosphorylating activity which is characteristic of abnormal tau HYPERPHOSPHORYLATION in Alzheimer's Disease is also provided.

REFERENCES:
patent: 5385915 (1995-01-01), Buxbabun et al.

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