Method of inducing osseous formation by implanting bone graft ma

Details Method of inducing osseous formation by implanting bone graft ma Method of inducing osseous formation by implanting bone graft ma

1982-09-30

1984-09-25

Apley, Richard J.

Surgery

Truss

Pad

128 92G, 128 92C, 3 1, A61F 100, A61F 504

Patent

active

044728409

ABSTRACT:
Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.

REFERENCES:
patent: 3551560 (1970-12-01), Thiele
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4347234 (1982-08-01), Wahlig et al.
Urist, Proc. Natl. Acad. Sci., USA 76: 1828-1932, 1979.

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