Method of inducing local anesthesia using microdroplets of a gen

Details Method of inducing local anesthesia using microdroplets of a gen Method of inducing local anesthesia using microdroplets of a gen

1983-06-17

1986-11-11

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514816, 514817, 514818, 514937, 514938, 514943, A61K 910, A61K 952

Patent

active

046222197

ABSTRACT:
Local anesthesia is induced using microdroplets of a general anesthetic in liquid form. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine.

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