Method of inducing immune tolerance

Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S154100, C424S156100

Reexamination Certificate

active

07744863

ABSTRACT:
A method of inhibiting Th1 immune response in a subject in need of such treatment which comprises administering to the subject effective amounts for inhibiting Th1 immune response of an anti-CD3 monoclonal antibody and IL-5 or an analogue or mimetic thereof.

REFERENCES:
patent: WO 94/28027 (1994-12-01), None
patent: WO 98/47531 (1998-10-01), None
Auchincloss, “Transplantation Immunology”, Bach and Auchincloss, Eds.,. Wiley-Liss, New York, 1995; Chapter 11, pp. 211-218.
Schroeder et al., J. Surg. Res. 2003, 111:109-119.
Chatenoud et al., J Immunol. Mar. 15, 1997;158(6):2947-54.
Chatenoud et al., Curr Opin Immunol. Dec. 2005;17(6):632-7.
He et al., Journal of the American Society of Nephrology, Sep. 1999, vol. 10, p. 703A.
Lopez et al., J Exp Med. Jan. 1, 1988;167(1):219-24.
Tang et al., J Exp Med. Jun. 7, 2004;199(11):1455-65.
Harley et al., Curr Opin Immunol. Dec. 1998;10(6):690-6.
Donald Leung, J Allergy Clin Immunol. May 2000;105(5):860-76.
Yawalkar et al., J Allergy Clin Immunol. Dec. 2000;106(6):1171-6.
Umland et al., J Immunol. Mar. 1, 1989;142(5):1528-35.
Sherer et al., Lupus. 2000;9(1):42-6.
Graber et al., J Biol Chem. Jun. 30, 1995;270(26):15762-9.
Plugariu et al., Biochemistry. Dec. 5, 2000;39(48):14939-49.
Whitty et al., Chem. Biol. Apr. 1999;6(4):R107-18.
Williamson et al., J Clin Pathol. Sep. 1985;38(9):1007-12.
Nagano et al., J Clin Immunol. Nov. 1999;19(6):422-7.
Assein et al., “Stable Polarization of Peripheral Blood T Cells Towards Type 1 or Type 2 Phenotype After Polyclonal Activation” European Journal of Immunology 28:532-539 (1998).
De Carli et al., “Immortalization with Herpesvirus Saimiri Modulates the Cytokine Secretion Profile of Established Th 1 and Th2 Human T Cell Clones” Journal of Immunology 151:5022-5030 (1993).
Flamand et al., “Anti-CD3 Antibodies Induce T Cells from Unprimed Animals to Secrete IL-4 Both InVitro and In Vivo” Journal of Immunology 144(8):2875-2882 (1990).
Hongwei et al., “Eosinophils in Acute Renal Allograft Rejection” Transplant Immunology 2(1):41-46 (1994).
Martinez et al., “Evidence for a Nonclassical Pathway of Graft Rejection Involving Interleukin 5 and Eosinophils” Transplantation 55(4):909-918 (1993).
Nicola (Ed.) “Interleukin-5 (IL-5)” InGuidebook to Cytokines and Their Receptorspp. 49-52 (1997).
Palmer and van Seventer, “Human T Helper Cell Differentiation Is Regulated by the Combined Action of Cytokines and Accessory Cell-Dependent Costimulatory Signals” J. of Immunology 158:2654-2662 (1997).
Piccinni et al., “Progesterone Favors the Development of Human T Helper Cells Producing Th2-type Cytokines and Promotes Both IL-4 Production and Membrane CD30 Expression in Established Th1 Cell Clones” Journal of Immunology 155:128-133 (1995).
Plain et al., “Induction of Specific Tolerance to Allografts in Rats by Therapy with Non-Mitogenic, Non-Depleting Anti-CD3 Monoclonal Antibody” Transplantation 67(4):605-613 (1999).
Posselt et al., “Induction of Donor-Specific Unresponsiveness by Intrathymic Islet Transplantation” Science 249:1293-1295 (1990).
Remuzzi et al., “Kidney Graft Survival in Rats Without Immunosuppressants After Intrathymic Glomerular Transplantation” Lancet 337:750-752 (1991).
Semnani et al., “Acquisition of Interleukin-5 Secretion by Human Naïve T-Helper Cells Is Regulated by Distinct Signals from Both the T-Cell Receptor/CD3 Complex and CD2” Scandinavian Journal of Immunology 47:436-443 (1998).
Kobayasi et al., J. Gastroenterol. (1998) 33:602-603.
Lin et al., Scand. J. Immunol. (1995) 4294):466-472.
Supplementary Partial European Search Report, for European patent application No. 00977328.4, 3 pages, 2003.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of inducing immune tolerance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of inducing immune tolerance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inducing immune tolerance will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4204554

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.