Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-05-11
1996-11-05
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 111, 424 149, 424 161, 424 165, 424 169, 424450, 424 932, 424 9321, 4351723, 4353201, 435 691, 435 695, 536 241, 935 6, 935 34, 935 59, 935 62, A61K 4800, A61K 5100
Patent
active
055717977
ABSTRACT:
The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. The radiation source may be will generally be in the form of a radionuclide, capable of gamma or beta emissions. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
REFERENCES:
patent: 5128126 (1992-07-01), Boniver
Weichselbaum et al (1992) Int J Radiation Oncology Biol Phys 24: 565-567.
Reuland et al (1991) Nucl Med Biol 18: 121-125.
Nedwin et al (1985) Nucleic Acids Research 13: 6361-6373.
Hallahan et al (1989) Proc Natl Acad Sci USA 86: 10104-10107.
Datta et al., "Ionizing radiation activates transcription of the EGR1 gene via CarG elements," Proc. Natl. Acad. Sci. USA, 89(21) :10149-10153, Nov., 1992.
Datta et al., "Reactive oxygen intermediates target CC(A/T) .sub.6 GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation," Proc. Natl. Acad. Sci. USA, 90(6) :2419-2422, Mar., 1993.
Gubits et al., "Expression of Immediate Early Genes After Treatment of Human Astrocytoma cells with Radiation and Taxol,"Int. J. Radiation Oncology Biol. Phys., 27(3) :637-642, Oct., 1993.
Luna et al., "Photodynamic Therapy Mediated Induction of Early Response Genes," Cancer Research, 54(5) :1374-1380, Mar., 1994.
Weichselbaum et al., "Radiation Induction of Immediate early Genes: Effectors of the Radiation-Stress Response," Int. J. Radiation Oncology Biol. Phys., 30(1) :229-234, Aug. 1994.
International Search Report dated Dec. 8, 1995.
K. Alexandropoulos, et al., "v-Fps-responsiveness in the Egr-1 Promoter is Mediated by Serum Response Elements", Nucleic Acids Research, 20(9): 2355-2359, 1992.
R. Attar, et al., "Expression Cloning of a Novel Zinc Finger Protein That Binds to the c-fos Serum Response Element", Molecular and Cellular Biology, 12 (5): 2432-2443, 1992.
D. Boothman, et al., "Identification and Characterization of X-Ray-induced Proteins in Human Cells", Cancer Research, 49: 2871-2878, 1989.
M. Brach, et al., "Ionizing Radiation Induces Expression and Binding Activity of the Nuclear Factor .kappa.B", The American Society for Clinical Investigation, Inc., 88: 691-695, 1991.
B. Christy, et al., "DNA Binding Site of the Growth Factor-Inducible Protein Zif268", Proc. Natl. Acad. Sci, USA, 86: 8737-8741, 1989.
S. Dalton, et al., "Characterization of SAP-1, a Protein Recruited by Serum Response Factor to the c-fos Serum Response Element", Cell, 68: 597-612, 1992.
M. Gessler, et al., "Homozygous Deletion in Wilms Tumours of a Zinc-Finger Gene Identified by Chromosome Jumping", Nature, 343: 774-778, 1990.
D. Hallahan, et al., "Protein Kinase C Mediates X-ray Inducibility of Nuclear Signal Transducers EGR1 and JUN", Proc. Natl. Acad. Sci. USA, 88: 2156-2160, 1991.
D. Hallahan, et al., "Tumor Necrosis Factor Gene Expression is Mediated by Protein Kinase C Following Activation by Ionizing Radiation", Cancer Research, 51: 4565-4569, 1991.
M. Lambert, et al., "X-ray-Induced Changes in Gene Expression in Normal and Oncogene-Transformed Rat Cell Lines", Journal of the National Cancer Institute, 80(18): 1492-1497, 1988.
S. Qureshi, et al., "v-Src Activates Mitogen-Responsive Transcription Factor Egr-1 via Serum Response Elements", The Journal of Biological Chemistry, 266(17): 10802-10806, 1991.
S. Qureshi, et al., "v-Src Activates Both Protein Kinase C-Dependent and Independent Signaling Pathways in Murine Fibroblasts", Oncogene, 6: 995-999, 1991.
M. Sherman, et al., "Ionizing Radiation Regulates Expression of the c-jun Protooncogene", Proc. Natl. Acad. Sci. USA, 87: 5663-5666, 1990.
M. Sherman, et al., "Regulation of Tumor Necrosis Factor Gene Expression by Ionizing Radiation in Human Myeloid Leukemia Cells and Peripheral Blood Monocytes", The American Society for Clinical Investigation, Inc., 87: 1794-1797, 1991.
V. Sukhatme, et al., "A Zinc Finger-Encoding Gene Coregulated with c-fos During GFrowth and Differentiation, and After Cellular Depolarization", Cell, 53: 37-43, 1988.
R. Weichselbaum et al., "X-Ray Sensitivity of Fifty-three Human Diploid Fibroblast Cell Strains From Patients with Characterized Genetic Disorders", Cancer Research, 40: 920-925, 1980.
R. Weichselbaum, et al., "Radiation-Resistant and Repair-proficient Human Tumor Cells May Be Associated with Radiotherapy Failure in Head-and Neck-Cancer Patients", Proc. Natl. Acad, Sci, USA, 83: 2684-2688, 1986.
R. Weichselbaum, et al., "In Vitro Radiobiological Parameters of Human Sarcoma Cell Lines", Int. J. Radiation Oncology Biol. Phys., 15: 937-942, 1988.
L. Witte, et al., "Effects of Irradiation on the Release of Growth Factors from Cultured Bovine, Porcine, and Human Endothelial Cells", Cancer Research, 49: 5066-5072, 1989.
Kufe Donald W.
Ohno Tsuneya
Weichselbaum Ralph R.
ARCH Development Corporation
Campell Bruce R.
LandOfFree
Method of inducing gene expression by ionizing radiation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inducing gene expression by ionizing radiation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inducing gene expression by ionizing radiation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2015288