Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2004-10-14
2008-03-25
Chen, Stacy B. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C424S218100
Reexamination Certificate
active
07348138
ABSTRACT:
This invention provides methods of inducing cell death withFlavivirusorPestiviruscapsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus includingFlavivirusorPestiviruscapsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirusand/or anti-Pestiviruscapsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus includingFlavivirusorPestivirusand a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses includingFlavivirusorPestivirus.
REFERENCES:
patent: 4722848 (1988-02-01), Paoletti et al.
patent: 5017487 (1991-05-01), Stunnenberg et al.
patent: 5077044 (1991-12-01), Stocker et al.
patent: 5110587 (1992-05-01), Paoletti et al.
patent: 5112749 (1992-05-01), Brey, III et al.
patent: 5174993 (1992-12-01), Paoletti
patent: 5206163 (1993-04-01), Renard et al.
patent: 5223424 (1993-06-01), Cochran et al.
patent: 5225336 (1993-07-01), Paoletti
patent: 5240703 (1993-08-01), Cochran
patent: 5242829 (1993-09-01), Panicali et al.
patent: 5254463 (1993-10-01), De Boer et al.
patent: 5294441 (1994-03-01), Curtiss, III
patent: 5294548 (1994-03-01), McLinden et al.
patent: 5310668 (1994-05-01), Ellis et al.
patent: 5350671 (1994-09-01), Houghton et al.
patent: 5387744 (1995-02-01), Curtiss, III et al.
patent: 5389368 (1995-02-01), Curtiss, III
patent: 5424065 (1995-06-01), Curtiss, III et al.
patent: 5451499 (1995-09-01), Cochran
patent: 5453364 (1995-09-01), Paoletti
patent: 5462734 (1995-10-01), Letchworth, III et al.
patent: 5470734 (1995-11-01), Sondermeijer et al.
patent: 5482713 (1996-01-01), Paoletti
patent: 5489529 (1996-02-01), De Boer et al.
patent: 5593972 (1997-01-01), Weiner et al.
patent: 5739118 (1998-04-01), Carrano et al.
patent: 5744140 (1998-04-01), Paoletti et al.
patent: 5837533 (1998-11-01), Boutin
patent: 5861290 (1999-01-01), Goldsmith et al.
patent: 5981505 (1999-11-01), Weiner et al.
patent: 6406689 (2002-06-01), Falkenberg et al.
patent: 6673895 (2004-01-01), Despres et al.
patent: WO 91/15574 (1991-10-01), None
patent: WO 93/22440 (1993-11-01), None
Chester M. Southam and Alice E. Moore, American Journal of Tropical Medicine and Hygiene, (1954), 3(1):19-50.
Heinz-Jurgen Thiel et al., Pestiviruses, Fields Virology, Lippincott-Raven Third Edition (1996) Chapter 33, Pestiviruses, pp. 1059-1063.
De Mitri et al., The Lancet, Feb. 18, 1995, 345:413-415.
Ramanathan et al. Virology, 2006, 345 :56-72.
Yang et al., Emerging Infectious Diseases, 2002, 8(12):1379-1384.
Colman, P.M., Research Immunology, 1994, 145:33-36.
Anderson, J.F., et al., “Direct submission,” Database GENBANK,US National Library of Medician, No. AF206517, Dec. 28, 1999, 1 page.
Anderson, J.F., et al., “Isolation of west nile virus from mosquitoes, crows, and a cooper's hawk in Connecticut,”Science, Dec. 17, 1999, 286, 2331-2333.
Chen, C., et al., “Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor,”J. Virology, Dec. 1997, 71(12), 9417-9426.
Marusawa, H., et al., “Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-κB activation,”J. Virology, Jun. 1999, 73(6), 4713-4720.
Parquet, M.D., et al., “West nile virus-inducted bax-dependent apoptosis,”FEBS Letts., 2001, 500, 17-24.
Ray, R.B., et al., “Inhibition of tumor necrosis factor (TNF-α)-mediated apoptosis by hepatitis C virus core protein,”J. Biological Chemistry, Jan. 23, 1998, 273(4), 2256-2259.
Ray, R.B., et al., “Suppression of apoptotic cell death by hepatitis C virus core protein,”J. Virology, 1996, 226, 176-182.
Ruggieri, A., et al., “Sensitization to fas-mediated apoptosis by hepatitis C virus core protein,”J. Virology, 1997, 229, 68-76.
Shrivastava, A., et al., “Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors,”J. Virology, Dec. 1998, 72(12), 9722-9728.
Yang, J.S., et al., “Induction of potent Th1-type immune responses from a novel DNA vaccine for west nile virus New York isolate (WNV-NY1999),”Dept. Pathology and Laboratory Medicine, Oct. 2001, 184, 809-816.
Zhu, N., et al., “Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis,”J. Virology, May 1998, 72(5), 3691-3697.
Neyts, J. et al., “Infections withFlaviviridae,”Verh K Acad Geneeskd Belg, 1999, 61, 661-697.
Salgame, P. et al., “An ELISA for detection of apoptosis,”Nucl Acids Res, 1997, 25(3), 680-681.
Seder, A. and Paul, W., “Acquisition of lymphokine-producing phenotype by CD4+ T cells,”Annu. Rev Immunol, 1994, 12, 635-673.
Sherlock, S., “The hepaticFlaviviridae: summary,”J Viral Hepat, 1999, 6, Suppl. 1,1-5.
Stewart, S. et al., “Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis following Cell Cycle Arrest,”J Virol, 1997, 71(7), 5579-5592.
Utz, P. and Anderson, P., “Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules,”Cell Death Differ, 2000, 7, 589-602.
Wide, L., “Solid Phase Antigen-Antibody Systems,”Radioimmune Assay Method, Kirkham, ed., E. & S. Livingstone, Edinburgh (1971) pp. 405-413.
GenBank Accession No. AAA81039: Collman, R. et al., “VPR protein (Human immunodeficiency virus type 1),” Aug. 10, 2000.
GenBank Accession No. AAA96744: Volchkov, V.E. et al., “envelope glycoprotein,” Apr. 11, 1996.
GenBank Accession No. AAC23593: Hsu et al., “Bcl-2 related ovarian death gene product BOD [Rattus norvegicus],” Mar. 11, 1999.
GenBank Accession No. AAC53582: Inohara, N. et al., “apoptosis activator Mtd [Mus musculus],” May 5, 1998.
GenBank Accession No. AAC57106: Moore, P.S. et al., “ORF 25; major capsid protein MCP homolog; EBV BcLF1 homolog [Human herpesvirus 8],” May 2, 1997.
GenBank Accession No. AAG30730: Tolou, H. et al., “polyprotein [Dengue virus type 2],” Nov. 8, 2000.
GenBank Accession No. AAG40164: Volchkov, V.E. et al., “nucleoprotein NP [Ebola virus],” Dec. 14, 2000.
GenBank Accession No. AAK54467: Yin, P. et al., “minor reovirus core protein mu2 [Mammalian orthoreovirus 2],” Jun. 15, 2001.
GenBank Accession No. AF094612: Pisano, M.R. et al., “Yellow fever virus strain Trinidad 79A isolate 788379, complete genome,” Jan. 20, 2000.
GenBank Accession No. AF196835: Lanciotti, R.S. et al., “West Nile virus strain NY99-flamingo382-99, complete genome,” Dec. 7, 2000.
GenBank Accession No. AF202541: Jia, X.Y. et al., “West Nile virus strain HNY1999 polyprotein (C, prM, E, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) gene, complete cds,” Dec. 16, 1999.
GenBank Accession No. AF206518: Anderson, J.F. et al., “West Nile virus isolate 2741, complete genome,” May 8, 2000.
GenBank Accession No. BAA00176: Coia, G. et al., “polyprotein [Kunjin virus],” Feb. 17, 1998.
GenBank Accession No. CAB75953: Barbarossa, L., “2a protein [cucumber mosaic virus],” Feb. 24, 2000.
GenBank Accession No. CAC22429: Zhang, H. et al., “Human Bad [Homo sapiens],” Jan. 17, 2001.
GenBank Accession No. D90194: Aihara, S. et al., “Japanese encephalitis virus strain SA(V), complete genome,” Feb. 7, 1999.
GenBank Acce
Muthumani Karuppiah
Weiner David B.
Yang Joo-Sung
Chen Stacy B.
Pepper Hamilton LLP
The Trustees of the University of Pennsylvania
LandOfFree
Method of inducing cell death using West Nile virus capsid... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inducing cell death using West Nile virus capsid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inducing cell death using West Nile virus capsid... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3976894