Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1995-05-19
1997-07-01
Nucker, Christine
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242181, 435236, 536 2372, A61K 3912, A61K 39193, C12N 704, C07H 2104
Patent
active
056435762
ABSTRACT:
A method of protecting a subject against a disease comprises administering a recombinant Venezuelan Equine Encephalitis (VEE) virus to the subject in an effective immunogenic amount, with the VEE virus containing a heterologous DNA segment, and with the heterologous DNA segment comprising a promoter operable in the subject operatively associated with a DNA encoding an immunogenic protein or peptide effective for protecting the subject from the disease. Preferred promoters are VEE 26S subgenomic promoters, and preferred immunogens are viral immunogens. Novel attenuating mutations useful in carrying out the invention are also disclosed.
REFERENCES:
patent: 5185440 (1993-02-01), Davis et al.
Kinney et al. "Attenuation of Venezuelan Equine Encephalitis Virus Strain TC-83 is encoded by the 5'-Noncoding Region and the E2 envelope glycoprotein" J. Virol vol. 67, No. 3, Mar. 1993, pp. 1269-1277.
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Davis Nancy L.
Grieder Franziska B.
Johnston Robert E.
Smith Jonathan F.
Bui Phuong T.
Nucker Christine
The University of North Carolina at Chapel Hill
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