Method of inducing a histamine agonist action on H.sub.2 recepto

Details Method of inducing a histamine agonist action on H.sub.2 recepto Method of inducing a histamine agonist action on H.sub.2 recepto

1991-09-06

1994-06-14

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483261, A61K 31415, C07D23354, C07D23366, C07D23388

Patent

active

053210395

ABSTRACT:
The invention claims as drugs which are active as agonists of the histamine H.sub.3 receptor, the O-[2-(4(5-imidazolyl)-ethyl] isothiourea, 4-(4(5)-imidazolyl) butyramidine and S-[2-(4(5)-imidazolyl)-ethyl] isourea as well as their N-methyl derivatives, these compounds being useful for the preparation of drugs to be used as hypnotic, sleep-inducer, tranquillizer, sedative, anxiolytic, anti-asthmatic and anti-inflammatory agents, notably for the bronchi, the skin or the eyes, or as anti-gastric ulcer agents.

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Van der Werf, et al., Trends in Pharmacological Sciences, vol. 10, No. 4, . 159-182, Apr. 1989.

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