Method of indicating rheumatoid factors

Details Method of indicating rheumatoid factors Method of indicating rheumatoid factors

1977-07-25

1980-01-22

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

232306, 23915, 424 1, 424 8, 424 12, G01N 3316

Patent

active

041848470

ABSTRACT:
A method of indicating rheumatoid factors, primarily such rheumatoid factors which belong to immunoglobulin classes other than the immunoglobulin class IgM, in an aqueous sample. The sample is reacted in the presence of the complement factor C1q in non-bound form with soluble, aggregated immunoglobulin labelled with one or more analytically indicatable atoms or groups to selectively precipitate such rheumatoid factors which, in the presence of C1q, are able to precipitate aggregated immunoglobulin, whereafter the analytically indicatable atoms or groups are indicated in the precipitation phase and/or in the solution.

REFERENCES:
patent: 3594466 (1971-07-01), Lille
patent: 3658982 (1972-04-01), Reiss
patent: 3689632 (1972-09-01), Mizushima
patent: 4062935 (1977-12-01), Masson
John S. Cowdery, Jr. et al., J. Immunol., 114(1), 5-9 (Jan. 1975).
Chemical Abstracts, 71:58955x (1969).
Chemical Abstracts, 74:2303c (1971).

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